Background: Lassa fever is of significant public health concern due to the high morbidity and mortality associated with the disease. There is need for the general public, especially those in the rural communities, to have adequate knowledge of Lassa fever as well as engage in proper measures that will prevent the occurrence of future outbreaks.
Objective: To assess the knowledge, attitude and preventive practices against Lassa fever of adult residents among a rural community in Edo State, Nigeria.
Methods: This was a descriptive cross-sectional study among adult residents of a rural community in Etsako Central LGA, Edo State. The participants were selected using multistage sampling technique. Data was collected using structured interviewer-administered questionnaires and data analysis was by IBM SPSS version 21.0. The level of significance was set at p < 0.05.
Results: Four hundred and sixty-five respondents with a mean age of 34.6 ± 14.7 years participated in the study. Majority (89.0%) had heard of Lassa fever and of these, 82.9% and 85.3% had poor knowledge of Lassa fever and positive attitude towards preventive measures against Lassa fever, respectively. Over half (59.1%) had poor preventive practices against Lassa fever. Knowledge, attitude and preventive practice was found to be better among educated respondents.
Conclusion: The study showed a gap in knowledge of Lassa fever and preventive practices against the disease among the respondents. Adequate measures such as enforcing policies against bush burning should be put in place by all stakeholders to ensure that this gap observed is bridged.
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IJID Reg
March 2025
Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, United Kingdom.
Objectives: Lassa fever (LF) poses a significant health burden in West Africa. The pathophysiology of LF and determinants of clinical spectrum of disease remain poorly understood. We performed a study to understand the correlation of blood inflammatory marker C-reactive protein (CRP), with LF disease severity.
View Article and Find Full Text PDFOne Health Outlook
January 2025
Medical Virology Unit, Faculty of Basic Medical and Applied Sciences, Lead City University and Primary Health Care Board, Ibadan, Oyo State, Nigeria.
Background: Dengue fever (DF) poses a growing global threat, necessitating a comprehensive one-health approach to address its complex interplay between human, animal, and environmental factors. In Oyo State, Nigeria, the true burden of DF remains unknown due to underdiagnosis and misdiagnosis as malaria, exacerbated by poor health-seeking behavior, weak surveillance systems, and inadequate health infrastructure. Adopting a one-health approach is crucial to understanding the dynamics of DF transmission.
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January 2025
Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
Lassa fever (LF), a viral hemorrhagic fever disease with a case fatality rate that can be over 20% among hospitalized LF patients, is endemic to many West African countries. Currently, no vaccines or therapies are specifically licensed to prevent or treat LF, hence the significance of developing therapeutics against the mammarenavirus Lassa virus (LASV), the causative agent of LF. We used in silico docking approaches to investigate the binding affinities of 2015 existing drugs to LASV proteins known to play critical roles in the formation and activity of the virus ribonucleoprotein complex (vRNP) responsible for directing replication and transcription of the viral genome.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu, China.
[This corrects the article DOI: 10.1371/journal.pone.
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