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Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma. | LitMetric

AI Article Synopsis

  • An elderly woman was diagnosed with invasive poorly differentiated thyroid cancer after experiencing a large cervical mass affecting her trachea, prompting an endotracheal biopsy.
  • Treatment initially included stenting and radiotherapy, but surgery was postponed due to a risk of pulmonary thromboembolism, leading to the use of lenvatinib to stabilize her condition.
  • Following stabilization, she underwent total thyroidectomy and radioiodine therapy, and now she is in good health with ongoing follow-ups, without additional adjuvant therapy.

Article Abstract

We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy.

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Source
http://dx.doi.org/10.2217/fon-2019-0099DOI Listing

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