AI Article Synopsis
- The study investigates risk factors for bacteremia in children with febrile neutropenia (FN) due to hemato-oncological malignancies, analyzing data from 150 patients under 18 years old.
- Among the participants, 23.3% had bacteremia, with coagulase-negative staphylococci being the most common bacteria found.
- Key risk factors identified include leukopenia, severe neutropenia, previous positive blood culture results, and episodes of hypotension, with past FN experiences increasing the risk significantly.
Article Abstract
Background/aim: Bacteremia remains an important cause of morbidity and mortality during febrile neutropenia (FN) episodes. We aimed to define the risk factors for bacteremia in febrile neutropenic children with hemato-oncological malignancies.
Materials And Methods: The records of 150 patients aged ≤18 years who developed FN in hematology and oncology clinics were retrospectively evaluated. Patients with bacteremia were compared to patients with negative blood cultures.
Results: The mean age of the patients was 7.5 ± 4.8 years. Leukemia was more prevalent than solid tumors (61.3% vs. 38.7%). Bacteremia was present in 23.3% of the patients. Coagulase-negative staphylococci were the most frequently isolated microorganism. Leukopenia, severe neutropenia, positive peripheral blood and central line cultures during the previous 3 months, presence of a central line, previous FN episode(s), hypotension, tachycardia, and tachypnea were found to be risk factors for bacteremia. Positive central line cultures during the previous 3 months and presence of previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively.
Conclusion: Presence of a bacterial growth in central line cultures during the previous 3 months and presence of any previous FN episode(s) were shown to increase bacteremia risk by 2.4-fold and 2.5-fold, respectively. These factors can predict bacteremia in children with FN.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018307 | PMC |
| http://dx.doi.org/10.3906/sag-1901-90 | DOI Listing |
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