AI Article Synopsis
- Atractylodis rhizoma is an important herbal product, but its efficacy varies, making authentication crucial for quality control and to prevent adulteration.
- A new HPLC-ELSD method was developed to quantify fructooligosaccharides (FOS) in Atractylodis rhizoma, identifying specific markers related to quality evaluation.
- A DP 5-based quantification method has been established, effectively addressing the lack of reference compounds and enhancing the quality control of Atractylodis rhizoma.
Article Abstract
Background: Atractylodis rhizoma, is the dried rhizomes of (Thunb.) DC. or (DC.) Koidz. Both of two are pharmacologically and economically important, while with differences in efficacy. Therefore, an authentication system is vital for evaluation the quality and discrimination adulteration of Atractylodis rhizoma. Fructooligosaccharides (FOS), which are regarded as functional ingredients in Atractylodis rhizoma, have not been used for quality control of Atractylodis rhizoma for shortage of reference compounds.
Results: A HPLC-ELSD method was developed for the quantification of FOS in Atractylodis rhizoma. And chemometrics analysis showed that 2 markers including content of degree of polymerization (DP) 12 and total content of DP 3-15 could be used as the main distinctive elements for quality evaluation of Atractylodis rhizome. Actually, the separation and purification of high DP FOS, such as DP 12, is still a challenge because of high polarity. Then DP 5-based qualification evaluation was investigated for quality control of Atractylodis rhizoma. The results showed that and could be clearly separated.
Conclusions: DP 5-based quantification method was credible and effectively adopted for solving the shortage of reference compounds and improving the quality control of Atractylodis rhizoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661778 | PMC |
| http://dx.doi.org/10.1186/s13065-019-0605-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intervention effects of Er Miao san on metabolic syndrome in Bama miniature pigs.
Phytomedicine
December 2024
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; Guangdong Research Center for Veterinary Traditional Chinese Medicine and Natural Medicine Engineering Technology, Guangzhou, China. Electronic address:
Background: Metabolic syndrome (MS) refers to a cluster of metabolic disorders characterized by systemic chronic inflammation. Er Miao San (EMS) is a classic traditional Chinese medicine compound containing Phellodendron amurense and Atractylodis rhizome at a ratio of 1:1, proven to be effective against inflammatory diseases in clinical practice. Nevertheless, the precise functions of EMS in treating MS and its underlying mechanism have yet to be elucidated.
View Article and Find Full Text PDFAtractylenolide Ⅲ partially alleviates tunicamycin-induced damage in porcine oocytes during in vitro maturation by reducing oxidative stress.
Anim Reprod Sci
December 2024
China-Japan Union Hospital of Jilin University, Rehabilitation Medicine Department, Changchun, Jilin, China. Electronic address:
Assisted reproductive technology (ART) is widely used to address infertility and enhance reproductive outcomes in livestock. Among various ART techniques, in vitro maturation (IVM) is commonly used to obtain high-quality oocytes but is susceptible to oxidative stress. In traditional Chinese medicine, Rhizoma Atractylodis Macrocephalae (Bai Zhu) is used to enhance maternal and fetal health.
View Article and Find Full Text PDF[Analysis of prescription rules for hyperlipidemia comorbid with hypertension based on latent structure model and association rules].
Zhongguo Zhong Yao Za Zhi
September 2024
Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
Based on the latent structure model and association rule analysis, the regularity of prescription for hyperlipidemia comorbid with hypertension was explored, and traditional Chinese medicine(TCM) pattern type was speculated to provide a reference for clinical pattern differentiation and treatment, and guideline establishment. The literature on the treatment of hyperlipidemia comorbid with hypertension by TCM was systematically searched on CNKI, Wanfang, VIP, and SinoMed academic platforms. The relevant information was extracted and a database was established using Microsoft Excel 2019.
View Article and Find Full Text PDFMulti-omics analysis reveals the neuroprotective effect of extract against Parkinson's disease in mouse.
J Tradit Chin Med
December 2024
College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Objective: To assess (ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice and related genes.
Methods: Examined mRNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease (PD) model's substantia nigra.
Results: ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum.
Research Progress with Atractylone as an Antitumor Agent.
Molecules
November 2024
College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
Atractylone is a sesquiterpenoid compound extracted from . As one of the main active components in the volatile oil of the genus, it has exhibited certain therapeutic effects, including anti-inflammatory, antiviral, antioxidant, antiallergic, antiangiogenic, and neuroprotective activities, among others. With further research on the chemical constituents and pharmacology of sesquiterpenes, research on the antitumor activity of Atractylone has also been further expanded.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!