In this article, we present a report from a national meeting titled, "Evolving Issues of Vascularized Composite Allotransplantation-A Symposium on Ethics, Policy, and Reimbursement Issues," which convened in September 2017. We discuss the maturation of vascularized composite allotransplantation from an emerging technology to becoming an extension of clinical practice for select patients with complex reconstructive needs. Viewpoints and action items were presented by and discussed among the 70+ clinicians, researchers, policymakers, ethicists, healthcare administrators, and third-party payers who attended the symposium with the goals of implementing a collaborative roadmap for vascularized composite allotransplantation growth, evaluation, and sustainability by establishing a unified plan to help address concerns of the public, policymakers, and healthcare finance. We review the current status of vascularized composite allotransplantation in clinical practice and summarize symposium discussions regarding ethical considerations, reimbursement, payer strategies, and standardization of data collection.
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http://dx.doi.org/10.1177/2050312119866944 | DOI Listing |
Am Heart J
January 2025
Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg, Germany.
Background And Rationale: In-stent restenosis (ISR) remains the leading cause of treatment failure following percutaneous coronary intervention (PCI) with contemporary drug-eluting stents. Especially in small caliber coronary arteries, restenosis is common following PCI and represents a treatment challenge. Drug-coated balloons (DCB) are an attractive alternative to stents for treatment of both ISR and small vessel disease.
View Article and Find Full Text PDFVascul Pharmacol
January 2025
INC Hospital, Curitiba, Brazil. Electronic address:
Introduction: Aspirin is commonly recommended for individuals who have experienced stroke or myocardial infarction (MI). Indobufen, a cyclooxygenase-1 inhibitor, has been studied as a potential alternative. We conducted a meta-analysis and trial sequential analysis (TSA) to compare indobufen with aspirin in patients requiring antiplatelet therapy.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Laboratory of Cell Biosystems, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
This study presents a comprehensive phyto- and histochemical analysis of three species: L., the Balkan endemic Guss., and the Bulgarian endemic Delip.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Departamento de Ciencias Jurídicas, Universidad Técnica Particular de Loja, Loja 1101608, Ecuador.
Epiphytic bryophytes are an important component in terms of the diversity and functioning of montane forests known as biodiversity hotspots. Bryophytes are highly dependent on their external environments because they are sensitive to environmental changes related to disturbance, fragmentation, air pollution, and climate change. The richness and composition of bryophytes in remnants of primary and secondary forests were analyzed, where the richness and cover were recorded on trunk bases of 120 trees.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Department of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Novel ferrite/polyurethane nanocomposites were synthesized using the in situ polymerization method after the addition of different spinel nanoferrite particles (copper, zinc, and copper-zinc) and examined as potential coatings for medical devices and implants in vascular tissue engineering. The influence of the nanoferrite type on the structure and functional characteristics of the polyurethane composites was investigated by FTIR, SWAXS, AFM, TGA, DSC, nanoindentation, swelling behavior, water contact angle, and water absorption measurements. Biocompatibility was evaluated by examining the cytotoxicity and adhesion of human endothelial cells and fibroblasts onto prepared composites and performing a protein adsorption test.
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