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| http://dx.doi.org/10.1073/pnas.1912448116 | DOI Listing |
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Longitudinal glioma monitoring via cerebrospinal fluid cell-free DNA.
Clin Cancer Res
December 2024
Mayo Clinic, Rochester, United States.
Purpose: Current methods for glioma response assessment are limited. This study aimed to assess the technical and clinical feasibility of molecular profiling using longitudinal intracranial CSF from patients with gliomas.
Experimental Design: Adults with gliomas underwent longitudinal intracranial CSF collection via Ommaya reservoirs or ventriculoperitoneal shunts.
Role of detrusor overactivity and interval between bladder sensations on the severity of overactive bladder symptoms in patients with multiple sclerosis.
Fr J Urol
December 2024
GRC 01, GREEN Group of clinical REsEarch in Neurourology, Sorbonne University, Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
Purpose: This study aimed to assess the relationship between kinetics of bladder sensations perception, detrusor overactivity (DO), and severity of overactive bladder (OAB) symptoms in patients with multiple sclerosis (PwMS).
Methods: All PwMS who underwent urodynamic assessment including three cystometries (20mL/min, 100mL/min, and 100mL/min with 4°C fluid) between June 2020 and October 2022 were included in this retrospective study. Data collected were bladder diaries, symptoms assessed with Urinary Symptom Profile (USP), bladder sensations with first desire to void (FDV) and strong desire to void (SDV) during the 20mL/min cystometry, and presence of DO.
Genotype and Other Common Variants are Associated with Computational Imaging Features of UIP.
Ann Am Thorac Soc
November 2024
University of Colorado, School of Medicine, Department of Medicine, Aurora, Colorado, United States;
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a complex disease, and variations in genetic profiles might influence unique clinical and imaging characteristics.
- Computational image analysis, or radiomics, provides a way to quantify and analyze CT scan features objectively in patients with pulmonary fibrosis.
- The study found that certain genetic variants correlated with deep learning-based classifications of the usual interstitial pneumonia (UIP) pattern on CT, suggesting that advanced imaging analysis could help in understanding genotype-phenotype relationships in lung diseases.
BW312 Hordeum vulgare semi-dwarf mutant exhibits a shifted metabolic profile towards pathogen resistance.
Metabolomics
October 2024
Plant Imaging & Mass Spectrometry (PIMS), Institut de Biologie Moléculaire Des Plantes, CNRS, Université de Strasbourg, 12 Rue du Général Zimmer, 67084, Strasbourg, France.
Introduction: Plant hormonal mutants, which do not produce or are insensitive to hormones, are often affected in their growth and development, but other metabolic rearrangements might be involved. A trade-off between growth and stress response is necessary for the plant survival.
Objectives: Here, we explore the metabolic profile and the pathogen resistance of a brassinosteroid-insensitive Hordeum vulgare L.
Efficacy and Safety of Advanced Therapies in Moderately-to-Severely Active Ulcerative Colitis: a Systematic Review and Network Meta-analysis.
Adv Ther
December 2024
Barts Health NHS Trust, London, UK.
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- This study compared the effectiveness and safety of biologics and small molecules for treating adults with moderately-to-severely active ulcerative colitis (UC).
- A systematic review and Bayesian network meta-analysis were conducted, including data from 30 studies for induction dosing and 22 for maintenance dosing of various treatments.
- Results showed that while many treatments had similar efficacy, mirikizumab and upadacitinib stood out for improving clinical response and remission, suggesting mirikizumab is a promising option for ongoing treatment.
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