AI Article Synopsis
- Interleukin 36 cytokines, particularly IL-36β and IL-36γ, are linked to autoimmune diseases, but their specific role in neuromyelitis optica spectrum disorders (NMOSD) is not well understood.
- A study measured serum levels of IL-36α, IL-36β, and IL-36γ in 50 NMOSD patients and 30 healthy controls, finding significantly elevated IL-36β and IL-36γ in NMOSD patients.
- Elevated IL-36β levels were positively associated with disease activity indicators such as relapse rates and disability scores, suggesting they could serve as important biomarkers for NMOSD.
Article Abstract
Background: Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) remains unclear.
Methods: We determined serum IL-36α, IL-36β and IL-36γ levels and assessed correlations with clinical characteristics in 50 NMOSD patients and 30 healthy controls (HC).
Results: The concentrations of serum IL-36β and IL-36γ were significantly higher in patients with NMOSD than in HCs and decreased during remission. Serum IL-36β levels were positively correlated with the annual relapse rate (ARR), spinal cord lesion length and Expanded Disability Status Scale (EDSS) scores.
Conclusions: Serum IL-36β and IL-36γ levels were related to disease activity in NMOSD patients and may be important biomarkers of NMOSD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681488 | PMC |
| http://dx.doi.org/10.1186/s12883-019-1415-2 | DOI Listing |
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