In order to establish the potential of [Mn]Cl as safe PET brain tracers, the radiation effective dose (ED) of [Mn]- and [Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of Mn allows a PET image resolution similar to that of F, activities below 15 MBq should be administered.
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