AntiSMASH analysis of genome DNA of CPCC 204980, a soil isolate with potent antibacterial activity, revealed a gene cluster for polycyclic xanthones. A subsequent chemical study confirmed that the microorganism produced polycyclic xanthone cervinomycin A () and the new congeners cervinomycins B (-). The structures of - were determined by comprehensive analyses of MS and NMR data, which indicated that - featured a common dihydro-D ring in the polycyclic xanthone core moiety of their molecules. - are toxic to human cancer cells and active against Gram-positive bacteria.
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Natural products with γ-pyrone scaffold from Streptomyces.
Appl Microbiol Biotechnol
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Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sun Moon-Ro 221, Tangjeong-Myeon, Asan-Si, 31460, Chungnam, Korea.
The Streptomyces sp. is considered the vast reservoir of bioactive natural products belonging to different classes like polyketides, terpenoids, lanthipeptides, and non-ribosomal peptides to name a few. The ubiquitous distribution of the genus makes them capable of producing distinct compounds.
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Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China. Electronic address:
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Hypericum sampsonii Hance, also known as Yuanbao Cao in Chinese, is a traditional medicinal herb from the Guttiferae family and has been widely used in China to treat various conditions, including dysentery, enteritis, mastitis, scrofula, and contusion. This review aims to provide a comprehensive overview of the botany, traditional uses, phytochemistry, biological activity and safety of and to highlight its potential for medical application and drug development. We searched several databases, i.
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Nat Prod Rep
November 2022
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Covering: up to the end of 2021Bacterial polycyclic xanthone natural products (BPXNPs) are a growing family of natural xanthones featuring a pentangular architecture with various modifications to the tricyclic xanthone chromophore. Their structural diversities and various activities have fueled biosynthetic and chemical synthetic studies. Moreover, their more potent activities than the clinically used drugs make them potential candidates for the treatment of diseases.
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