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Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread immune dysregulation that affects multiple organ systems, including the skin and cardiovascular system. The crosstalk between different cell death pathways-such as apoptosis, necroptosis, and neutrophil extracellular trap (NETosis), plays a pivotal role in the pathogenesis of SLE, influencing both cutaneous and cardiac manifestations. Cutaneous lupus erythematosus (CLE) is one of the most common early signs of SLE, affecting up to 80% of patients.
View Article and Find Full Text PDFSurvey on the prevalence of trypanosomosis in small ruminants and on tsetse distribution in Dedesa and Bedele districts, Buno Bedele Zone, Ethiopia.
Comp Immunol Microbiol Infect Dis
January 2025
Bedele Animal Health Diagnostic Center, Ethiopia.
Background: African animal trypanosomosis (AAT) is one of the most serious diseases with ongoing detrimental effects on animal health and food production.
Methods: A cross-sectional study was conducted in the Bedele and Dedesa districts of Buno Bedele Zone, Southwest Ethiopia, to determine the prevalence of trypanosomosis and its vector distributions in small ruminants. Blood samples collected from a total of 384 small ruminants were examined for trypanosomosis via hematological analysis.
Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease.
Respir Res
January 2025
Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Background: Neutrophil extracellular trap (NET) formation has been implicated as a pathogenic mechanism in both rheumatoid arthritis (RA) and interstitial lung disease (ILD). However, the role of NETs in RA-associated ILD (RA-ILD) and the mechanisms driving NET formation remain unclear. This study aimed to assess the involvement of NETs in RA-ILD and elucidate the underlying mechanisms.
View Article and Find Full Text PDFAdolescent anorectal malformations: Case series about 3 cases.
Int J Surg Case Rep
January 2025
Surgery Department, Faculty of medicine and public health, Evangelical University in Africa, Bukavu, South Kivu, the Democratic Republic of the Congo; Surgery Department, Panzi General Referral Hospital, Bukavu, South Kivu, the Democratic Republic of the Congo; Surgery Department, Faculty of medicine, Kisangani University, Kisangani, Tsopo, the Democratic Republic of the Congo.
Introduction: Anorectal malformations (ARM) are an anatomically complex in which anorectum is either agenesic or communicates with neighboring organs. They are rarely found in adolescents. The aim of this study was to describe and discuss according to literature the three cases of ARM in adolescents.
View Article and Find Full Text PDFLanthanide Metal-Organic Framework Flowers for Proteome Profiling and Biomarker Identification in Ultratrace Biofluid Samples.
ACS Nano
January 2025
Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.
Identifying effective biomarkers has long been a persistent need for early diagnosis and targeted therapy of disease. While mass spectrometry-based label-free proteomics with trace cell has been demonstrated, deep proteomics with ultratrace human biofluid remains challenging due to low protein concentration, extremely limited patient sample volume, and substantial protein contact losses during preprocessing. Herein, we proposed and validated lanthanide metal-organic framework flowers (MOF-flowers), as effective materials, to trap and enrich protein in biofluid jointly through cation-π interaction and O-Ln coordination.
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