Diagnostic features, treatment, and outcome of dogs with inflammatory protein-losing enteropathy.

J Vet Intern Med

University of Edinburgh, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, Hospital for Small Animals, Midlothian, United Kingdom.

Published: September 2019

Background: Protein-losing enteropathy (PLE) because of chronic inflammatory enteropathy (CIE) in dogs is often treated with a combination of glucocorticoids and second-line immunosuppressant (SLI). This combined approach might not be necessary in all dogs.

Hypothesis/objectives: To describe diagnostic features and outcomes of dogs with PLE treated with glucocorticoids alone (group P) or with glucocorticoids and SLI (group S).

Animals: Thirty-one dogs with PLE.

Material And Methods: Retrospective analysis of signalment data from diagnostic procedures, treatment, and outcome of dogs with CIE/PLE (from 2015 to 2017), using the hospital's digital case database. Dogs with hypoalbuminemia and CIE were included. Because of a stepwise treatment algorithm, dogs were allocated to group P or S. Time to serum albumin concentrations ≥20 g/L and survival data were collected. Dogs were additionally categorized by their albumin and cobalamin serum concentrations. Multivariate and univariate analysis as well as Pearson's correlation and Kaplan-Maier survival analysis were performed.

Results: Seventeen dogs were included in group P and 14 in group S. World Small Animal Veterinary Association score of the duodenum was different between groups (P = .05), but none of the other examined data. Median time until serum albumin reached >20 g/L was 13 days. Median survival time after start of treatment was 85 days (range, 13-463 days) in group P and 166 days (range, 8-390 days) in group S.

Conclusion And Clinical Importance: No routine diagnostic test was predictive of clinical response, treatment group, or outcome. Glucocorticoid treatment alone can be appropriate in dogs with PLE.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766500PMC
http://dx.doi.org/10.1111/jvim.15571DOI Listing

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