Development of a database on key characteristics of human carcinogens.

J Toxicol Environ Health B Crit Rev

McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

Published: May 2020

A database on mechanistic characteristics of human carcinogenic agents was developed by collecting mechanistic information on agents identified as human carcinogens (Group 1) by the International Agency for Research on Cancer (IARC) in the . A two-phase process is described for the construction of the database according to 24 toxicological endpoints, derived from appropriate test systems that were acquired from data obtained from the mechanisms sections of the IARC Monographs (Section 4) and a supplementary PubMed search. These endpoints were then aligned with 10 key characteristics of human carcinogens that reflect the broader attributes of these agents relating to the development of cancer in humans. The considerations involved in linking of toxicological endpoints to key characteristics are described and specific examples of the determination of key characteristics for six specific agents (tamoxifen, hepatitis B virus, arsenic, ultraviolet and solar radiation, tobacco smoking, and dioxin) are provided. Data for humans and animals were tabulated separately, as were results for and for sources of information. The database was constructed to support a separate analysis of the expression of these endpoints by 86 Group 1 carcinogens, and along with an analysis of the key characteristics of these agents.

Download full-text PDF

Source
http://dx.doi.org/10.1080/10937404.2019.1642593DOI Listing

Publication Analysis

Top Keywords

key characteristics
20
characteristics human
12
human carcinogens
12
toxicological endpoints
8
characteristics
6
key
5
agents
5
development database
4
database key
4
human
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!