AI Article Synopsis
- Immunotherapies targeting amyloid β (Aβ) and α-synuclein (α-syn) are being explored for treating dementia with Lewy bodies, but their effectiveness as single or combined treatments is unclear.
- Researchers tested different AFFITOPE® peptides on mice to assess their impact on Aβ and α-syn levels, neuron health, and behavioral outcomes.
- Results showed that while AD02 (Aβ-targeting) was better at reducing Aβ and improving certain behaviors, the combination of AD02 and PD-AFF1 (α-syn-targeting) had some added benefits, indicating that specific immunotherapy could be promising for dementia treatment.
Article Abstract
Introduction: Immunotherapeutic approaches targeting amyloid β (Aβ) protein and tau in Alzheimer's disease and α-synuclein (α-syn) in Parkinson's disease are being developed for treating dementia with Lewy bodies. However, it is unknown if single or combined immunotherapies targeting Aβ and/or α-syn may be effective.
Methods: Amyloid precursor protein/α-syn tg mice were immunized with AFFITOPEs® (AFF) peptides specific to Aβ (AD02) or α-syn (PD-AFF1) and the combination.
Results: AD02 more effectively reduced Aβ and pTau burden; however, the combination exhibited some additive effects. Both AD02 and PD-AFF1 effectively reduced α-syn, ameliorated degeneration of pyramidal neurons, and reduced neuroinflammation. PD-AFF1 more effectively ameliorated cholinergic and dopaminergic fiber loss; the combined immunization displayed additive effects. AD02 more effectively improved buried pellet test behavior, whereas PD-AFF1 more effectively improved horizontal beam test; the combined immunization displayed additive effects.
Discussion: Specific active immunotherapy targeting Aβ and/or α-syn may be of potential interest for the treatment of dementia with Lewy bodies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503212 | PMC |
| http://dx.doi.org/10.1016/j.jalz.2019.02.002 | DOI Listing |
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