Effect of collimator angle on HyperArc stereotactic radiosurgery planning for single and multiple brain metastases.

We assessed the effect of collimator angle on the dosimetric parameters for targets and organs at risk (OARs) for collimator-optimized HA (CO-HA) and non-CO-HA (nCO-HA) plans. The nCO-HA and CO-HA plans were retrospectively generated for 26 patients (1 to 8 brain metastases). The dosimetric parameters for planning target volume (homogeneity index [HI]; conformity index [CI]; gradient index [GI]) and for OARs were compared. The modulation complexity score for volumetric modulated arc therapy (MCSV) and monitor units (MUs) were calculated. Doses were measured using the electronic portal imaging device and compared with the expected doses. Dosimetric parameters of the HI, CI, and GI for single (n = 12) and multiple (n = 14) metastases cases were comparable (p > 0.05). For multiple metastases cases, the CO-HA plan provided lower V, V, V, V for brain tissue compared to the nCO-HA plan (p < 0.05). Doses for OARs (D) (brainstem, chiasm, Hippocampus, lens, optic nerves, and retinas) were comparable (p > 0.05). For multiple metastases cases, the CO-HA plan resulted in less complex multileaf collimator (MLC) patterns (MCSV = 0.19 ± 0.04, p < 0.01), lower MUs (8596 ± 1390 MUs, p < 0.01), and shorter beam-on time (6.2 ± 1.0 min, p < 0.01) compared to the nCO-HA plan (0.16 ± 0.04, 9365 ± 1630, and 6.7 ± 1.2 for MCSV, MUs, and beam-on time, respectively). For both treatment approach, the equivalent gamma passing rate was obtained with the 3%/3 mm and 2%/2 mm criteria (p > 0.05). The collimator optimization in the HA planning reduced doses to brain tissues and improved the treatment efficacy.