Under the Safe System framework, Road Authorities have a responsibility to deliver inherently safe roads and streets. Addressing this problem depends on knowledge of the road network safety conditions and the number of funds available for new road safety interventions. It also requires the prioritisation of the various interventions that may generate benefits, increasing safety, while ensuring that reasonable steps are taken to remedy the deficiencies detected within a reasonable timeframe. In this context, Road Safety Inspections (RSI) are a proactive tool for identifying safety issues, consisting of a regular, systematic, on-site inspection of existing roads, covering the whole road network, carried out by trained safety expert teams. This paper aims to describe how topic modelling can be effectively used to identify co-occurrence patterns of attributes related to the run-off-road crashes, as well as the corresponding patterns of road safety interventions, as described in the RSI reports. We apply latent Dirichlet allocation (LDA), a widespread method for fitting a topic model, to analyse the topics mentioned in RSI reports, divided into two groups: problems found; and proposed solutions. For this study, 54 RSI gathered over six years (2012-2017) were analysed, covering 4011 km of Irish roads. The results indicate that important keywords relating to the "forgiving roadside" and "clear zone" concepts, as well as the relevant European technical standards (CEN-EN1317 and EN 12,767), are absent from the extracted latent topics. We also found that the frequency of topics related to roadside safety is higher in the problems record set than in the solutions record set, meaning that problems are more easily identified and related to the roadside area than interventions may be. This paper presents methodological empirical evidence that the LDA is appropriate for identifying the co-occurrence patterns of attributes related to the ROR crashes in road safety inspections' reports, as well as the interventions' patterns associated with these crashes. Also, it provides valuable information aimed to determine the extent to which national road authorities in Europe and their contractors are currently capable of implementing and maintaining compliance with roadside standards and guidelines throughout the life cycle of roads.
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http://dx.doi.org/10.1016/j.aap.2019.07.021 | DOI Listing |
ChemSusChem
January 2025
Yangzhou University, College of Chemistry and Chemical Engineering, Siwangting road, NO.180, 225002, Yangzhou, CHINA.
The integration of metal-organic frameworks (MOFs) with functional materials has established a versatile platform for a wide range of energy storage applications. Due to their large specific surface area, high porosity, and tunable structural properties, MOFs hold significant promise as components in energy storage systems, including electrodes, electrolytes, and separators for alkali metal-ion batteries (AIBs). Although lithium-ion batteries (LIBs) are widely used, their commercial graphite anode materials are nearing their theoretical capacity limits, and the scarcity of lithium and cobalt resources increases costs.
View Article and Find Full Text PDFMol Pharm
January 2025
Drug Product Development-Steriles, Medicine Development and Supply, GSK, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Therapeutic monoclonal antibody (mAb) drug products are increasingly used to treat both chronic and acute diseases. These mAb drug products are often developed for subcutaneous (SC) injection to simplify dosing compared with intravenous (IV) infusion. For SC injection, the mAb liquid drug product is typically filled in a vial for use with a syringe or in a prefilled syringe, which can then be assembled into a safety syringe device or an autoinjector for direct administration.
View Article and Find Full Text PDFEur J Anaesthesiol
February 2025
From the Servicio de Anestesia y Reanimación, Hospital Universitario Gregorio Marañón, Calle de O'Donnell, 48, 28009 Madrid, Madrid, Spain (NB), the Servicio de Anestesia, Hospital Universitario Sanitas La Zarzuela, Madrid, c/ Pleyades, 25, 28023 Madrid, Spain (NB), the Servicio de Anestesia y Reanimación, Hospital Universitario La Paz, Madrid, P° de la Castellana, 261, 28046 Madrid, Spain (IVG), the Department of Paediatric and Obstetric Anaesthesiology, Juliane Marie Centre, Rigshospitalet & Institute of Clinical Medicine, University Hospital of Copenhagen, Copenhagen, Denmark (AA, KL), the University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany (PK, SR), the Division of Anesthesia Critical Care and Pain, Tel Aviv Sourasky Medical Center affiliated with the Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv Israel (CFW), the London North West NHS University Trust, Watford Road, London, UK HA1 3UJ (NL), the Department of Anesthesia & Intensive Care Medicine, Liège University Hospital, Belgium (PYD), the Servicio de Anestesia y Reanimación. Hospital Universitario Fundación Jiménez Díaz. Av. de los Reyes Católicos, 2. 28040 Madrid. Spain (EGA), the Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Center, Hebrew University, Shmuel Beyth St 12, Jerusalem, 9103102 Israel (AI), the Department of Anesthesia and Intensive Care, Akademiska Sjukhuset, Sjukhusvägen, 75185, Uppsala, Sweden (AK), the Department of Anesthesia, Beilinson Hospital, Petach Tikvah, Israel affiliated with Tel Aviv University Medical School (SOZ), the Department of Anaesthesiology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands (OvdB), the Department of Cardiovascular Sciences, KU Leuven, and Department of Anaesthesiology, UZ Leuven, Belgium (MvdV), the Department of Anaesthesia, Intensive Care and Pain Medicine, University General Hospital of Valencia, Methodology Department, European University of Valencia, Valencia, Spain (CSR).
Background: Labour epidural analgesia reportedly fails in up to 10 to 25% of cases. A joint taskforce of European Society of Anaesthesiology and Intensive Care (ESAIC) experts was created to develop this focused guideline on the management of failing epidural analgesia in a previously well functioning epidural catheter.
Design: Six clinical questions were defined using a PICO (Population/Intervention/Comparison/Outcome) strategy to conduct a systematic literature search.
Cureus
December 2024
Department of Psychiatry, All India Institute of Medical Sciences, Kalyani, Kalyani, IND.
Background: Road traffic accidents (RTAs) are a critical public health problem leading to significant morbidity, mortality, and socioeconomic losses. Despite known risk factors like substance use and sleep-related problems, there is limited research on the prevalence of these factors among drivers who met with RTAs. Hence, this study aimed to gain insight into the prevalence of substance use and sleep-related problems among this population attending a trauma center in the northern State of India.
View Article and Find Full Text PDFAntiviral Res
December 2024
State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou, 510530, China; Guangzhou Henovcom Bioscience Inc, 11 Kaiyuan Rd, Guangzhou, Guangdong, China. Electronic address:
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global public health crisis and continues to pose grave threats to human health. The efficacy of current vaccines and therapeutics is likely limited for future emerging strains due to the highly mutative nature of the virus, underscoring an urgent need for the development of new, potent antiviral agents. In this study, we report the design and synthesis of a series of novel 2'-deoxy-2'-spirooxetane-7-deazapurine nucleoside analogs as potential inhibitors of SARS-CoV-2 replication.
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