Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077977 | PMC |
| http://dx.doi.org/10.1016/j.scr.2019.101495 | DOI Listing |
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