Purpose: To determine the optimal combination of low b‑values to generate perfusion information from intravoxel incoherent motion (IVIM) in patients with acute ischemic stroke (AIS) considering the time constraints for these patients.
Methods: A retrospective cohort study of AIS patients with IVIM MRI was performed. A two-step voxel-by-voxel postprocessing was used to derive IVIM perfusion fraction maps with different combinations of b values. Signal values within regions of ischemic core, non-infarcted ischemic hemisphere, and contralateral hemisphere were measured on IVIM (f, D, fD, D) parameter maps. Bland-Altman analysis and the Dice similarity coefficient were used to determine quantitative and spatial agreements between the reference standard IVIM (IVIM with 6 b values of 0, 50, 100, 150, 200, 1000 s/mm) and other combinations of b values. Significance level was set at p < 0.05.
Results: There were 58 patients (36 males, 61.3%; mean age 70.2 ± 13.4 years) included. Considering all IVIM parameters, the combination of b values of 0, 50, 200, 1000 was the most consistent with our reference standard on Bland-Altman analysis. The best voxel-based overlaps of ischemic regions were on IVIM D, while there were good voxel-based overlaps on IVIM f.
Conclusion: The IVIM with these four b values collects diffusion and perfusion information from a single short MRI sequence, which may have important implications for the imaging of AIS patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00062-019-00817-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multiparametric functional MRI of the kidneys - evaluation of test-retest repeatability and effects of different manual and automatic image analysis strategies.
Rofo
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Multiparametric MRI is a promising technique for noninvasive structural and functional imaging of the kidneys that is gaining increasing importance in clinical research. Still, there are no standardized recommendations for analyzing the acquired images and there is a need to further evaluate the accuracy and repeatability of currently recommended MRI parameters. The aim of the study was to evaluate the test-retest repeatability of functional renal MRI parameters using different image analysis strategies.
View Article and Find Full Text PDFPerfusion Showdown: Comparison of Multiple MRI Perfusion Techniques in the Grading of Pediatric Brain Tumors.
AJNR Am J Neuroradiol
December 2024
From the Department of Diagnostic Medicine, Dell Medical School at The University of Texas at Austin, Austin, TX, USA (C.Y.H.), Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA (N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA (E.C., P.R.T., S.A.P.), Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA (P.R.T., S.A.P.), and the Department of Radiology at Texas Children's Hospital, Houston, TX, USA (S.F.K.).
Background And Purpose: There are multiple MRI perfusion techniques, with limited available literature comparing these techniques in the grading of pediatric brain tumors. For efficiency and limiting scan time, ideally only one MRI perfusion technique can be used in initial imaging. We compared DSC, DCE, and IVIM along with ADC from DWI for differentiating high versus low grade pediatric brain tumors.
View Article and Find Full Text PDFIntravoxel incoherent motion diffusion-weighted imaging in nasopharyngeal carcinoma: comparison of the turbo spin-echo and echo-planar imaging techniques.
Quant Imaging Med Surg
December 2024
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- This study compares turbo spin echo with intravoxel incoherent motion (TSE-IVIM) to traditional echo-planar imaging (EPI-IVIM) in detecting nasopharyngeal carcinoma (NPC), aiming to identify optimal imaging strategies.
- TSE-IVIM showed superior qualitative assessments, such as reduced susceptibility artifacts and better image quality in depicting anatomical structures related to NPC compared to EPI-IVIM.
- Both subjective and quantitative measures highlighted TSE-IVIM's advantages, suggesting it could improve pre-treatment staging MR examinations for NPC patients.
Investigation of diffusion time dependence of apparent diffusion coefficient and intravoxel incoherent motion parameters in the human kidney.
Magn Reson Med
December 2024
Department of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany.
Purpose: To characterize the diffusion time (Δ) dependence of apparent diffusion coefficient (ADC) and intravoxel incoherent motion-related parameters in the human kidney at 3 T.
Methods: Sixteen healthy volunteers underwent an MRI examination at 3 T including diffusion-weighted imaging at different Δ ranging from 24.1 to 104.
Evaluation of Renal Perfusion: A Comparative Study between Intravoxel Incoherent Motion (IVIM) Imaging and Arterial Spin Labeling (ASL) to Assess Renal Blood Flow in Rodents.
Magn Reson Med Sci
December 2024
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- The study aimed to compare the effectiveness of intravoxel incoherent motion (IVIM) imaging and arterial spin labeling (ASL) in evaluating renal blood flow in rodent models of acute kidney injury (AKI).
- Researchers tested three fitting methods on diffusion-weighted imaging data to assess the reliability of pseudo-diffusion parameters and their ability to correlate with renal blood flow.
- Findings revealed that while ASL effectively detected a significant drop in renal blood flow due to AKI, IVIM's pseudo-diffusion parameters were not reliable or correlated, suggesting the need for careful consideration when interpreting results using IVIM in kidney studies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!