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Health Care Contact Days for Older Adults Enrolled in Cancer Clinical Trials.
JAMA Netw Open
March 2025
SWOG Statistics and Data Management Center, Fred Hutchinson Cancer Center, Seattle, Washington.
Importance: Contact days-days with health care contact outside the home-are a measure of how much of a patient's life is consumed by health care. Clinical trials, with a more uniform patient mix and protocolized care, provide a unique opportunity to assess whether burdens differ by individuals' sociodemographic backgrounds.
Objective: To characterize patterns of contact days for older adults with cancer participating in clinical trials.
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review.
Hum Vaccin Immunother
December 2025
Pfizer Vaccines, Collegeville, USA.
This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020-July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing of vaccination relative to infection or PCC-onset. Comparisons of adjusted vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) across study characteristics known to impact PCC burden or VE against other COVID-19 endpoints were possible for 31 studies where vaccination preceded infection.
View Article and Find Full Text PDFPretreatment Liquid Biopsy and Clinicopathologic Features in HPV-Associated Oropharyngeal Squamous Cell Carcinoma.
JAMA Otolaryngol Head Neck Surg
March 2025
Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Despite the favorable prognosis for HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC), efforts to de-escalate treatment intensity, while maintaining low recurrence and mortality rates, have proven challenging. Identifying appropriate prognostic factors remains elusive; however, the association of pretreatment circulating tumor tissue viral-modified HPV (TTMV-HPV) DNA level with known characteristics of disease burden-clinical staging, characteristics of pretreatment imaging, and aggressive histopathologic features of surgical specimen-may offer insights that could shift treatment paradigms for HPV+ OPSCC.
Objective: To investigate the association of pretreatment TTMV-HPV DNA levels with clinical, radiologic, histopathologic, and outcome metrics in patients with HPV+ OPSCC.
External Validation and Comparison of Current Scoring Systems in Encrusted Ure-teral Stent Management: a Multicenter Study.
Int Braz J Urol
March 2025
Department of Urology, Health Sciences University Adana City Training and Research Hospital, Adana, Turkey.
Purpose: To compare the external validation of four existing scoring systems for encrusted ureteral stents (EUS) and their relationship with stent indwelling time, stone-free rates, multiple surgery sessions, multimodal procedures, and prolonged operation times exceeding 120 minutes in total.
Materials And Methods: The data of 208 patients who underwent surgery for EUS reviewed. All EUSs were evaluated with 4 scoring systems: ESB (encrusted stone burden), FECal (forgotten, encrusted, calcified), KUB (kidney, ureter and bladder), V-GUES (visual grading for ureteral stone burden).
Evaluating the Rehabilitation Needs of Stroke Patients in China: A Trend Analysis From 1990 to 2019.
Brain Behav
March 2025
Department of Neurology, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong Province, China.
Background: Stroke remains a leading cause of death and long-term disability in China. Rehabilitation is known to be an effective intervention for reducing disability among stroke survivors. This study seeks to quantify the rehabilitation needs of stroke patients in China by analyzing prevalence and years lived with disability (YLDs).
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