Humans consistently coordinate their joints to perform a variety of tasks. Computational motor control theory explains these stereotypical behaviors using optimal control. Several cost functions have been used to explain specific movements, which suggests that the brain optimizes for a combination of costs and just varies their relative weights to perform different tasks. In the case of tunable human-machine interfaces, we hypothesize that the human-machine interface should be optimized according to the costs that the user cares about when making the movement. Here, we study how the relative weights of individual cost functions in a composite movement cost affect the optimal control signal produced by the user and the mapping between the user's control signals and the machine's output, using prosthesis control as a specific example. This framework was tested by building a hierarchical optimization model that independently optimized for the user control signal and the virtual dynamics of the device. Our results indicate the feasibility of the approach and show the potential for using such a model in prosthesis tuning. This method could be used to allow clinicians and users to tune their prosthesis based on costs they actually care about; and allow the platforms to be customized for the unique needs of every patient.
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http://dx.doi.org/10.1109/ICORR.2019.8779397 | DOI Listing |
Viruses
December 2024
Xinjiang Key Laboratory of New Drug Study and Creation for Herbivorous Animals (XJ-KLNDSCHA), College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China.
Porcine bocavirus (PBoV), classified within the genus Bocaparvovirus, has been reported worldwide. PBoV has been divided into group 1, group 2, and group 3. PBoV group 3 (G3) viruses are the most prevalent in China.
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December 2024
U.S. Geological Survey, Upper Midwest Water Science Center, 5840 Enterprise Drive, Lansing, MI 48911, USA.
Since late 2021, outbreaks of highly pathogenic avian influenza virus have caused a record number of mortalities in wild birds, domestic poultry, and mammals in North America. Wetlands are plausible environmental reservoirs of avian influenza virus; however, the transmission and persistence of the virus in the aquatic environment are poorly understood. To explore environmental contamination with the avian influenza virus, a large-volume concentration method for detecting infectious avian influenza virus in waterbodies was developed.
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November 2024
Department of Infectious Diseases, Molecular Virology, Section Virus-Host Interactions, Heidelberg University, 69120 Heidelberg, Germany.
The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild-type (WT) isolates was enabled by the expression of SEC14L2 and by inhibitors targeting deleterious host factors. Here, we aimed to optimize cell culture models to allow infection with HCV from patient sera.
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November 2024
Department of Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
Wolbachia-based mosquito control strategies have gained significant attention as a sustainable approach to reduce the transmission of vector-borne diseases such as dengue, Zika, and chikungunya. These endosymbiotic bacteria can limit the ability of mosquitoes to transmit pathogens, offering a promising alternative to traditional chemical-based interventions. With the growing impact of climate change on mosquito population dynamics and disease transmission, Wolbachia interventions represent an adaptable and resilient strategy for mitigating the public health burden of vector-borne diseases.
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November 2024
Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
In this study, we introduce a novel approach that integrates interpretability techniques from both traditional machine learning (ML) and deep neural networks (DNN) to quantify feature importance using global and local interpretation methods. Our method bridges the gap between interpretable ML models and powerful deep learning (DL) architectures, providing comprehensive insights into the key drivers behind model predictions, especially in detecting outliers within medical data. We applied this method to analyze COVID-19 pandemic data from 2020, yielding intriguing insights.
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