The brain injury that results in cerebral palsy CP may adversely affect fine motor control of the hand. The degradation of manual dexterity in the fingers profoundly impacts overall functionality of the upper limb, yet research efforts to facilitate rehabilitation of finger individuation in children with CP have been limited. This study describes the development of an integrated hardware and software platform for training and evaluating finger individuation. A pneumatically actuated glove provides extension assistance or flexion resistance independently to each digit in concert with playing a virtual reality keyboard. This setup enables intensive and efficient practice of fine motor control of either or both hands. Bimanual training options range from mirror movements to fully independent motions and rhythms in each hand, thereby enabling maintenance of the proper level of challenge. Additionally, an instrument was created to provide assessment of individuated fingertip force generation in order to evaluate effectiveness of the training. Preliminary data were obtained from children both with and without CP using this tool.
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http://dx.doi.org/10.1109/ICORR.2019.8779537 | DOI Listing |
Acta Orthop Belg
December 2024
Atypical mycobacteria can cause rare and atypical infections of the hand. We report the case of an immunocompetent 46-year-old male initially presenting with thumb felon and progressively developing symptoms of carpal tunnel syndrome, tenosynovitis of multiple fingers and a sporotrichoid lymphocutaneous infection causing chronic cutaneous lesions all over the body. We would like to highlight the diagnostic and therapeutic difficulties of these atypical infections, which mimic other conditions and can cause a lot of morbidity.
View Article and Find Full Text PDFIUBMB Life
January 2025
Senior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Hepatocellular carcinoma (HCC) ranks among the most prevalent types of cancer globally. Zinc finger protein 169 (ZNF169) holds significant importance as a transcription factor, yet its precise function in HCC remains to be elucidated. This study aims to examine the clinical importance, biological functions, and molecular pathways associated with ZNF169 in the development of HCC.
View Article and Find Full Text PDFInt J Clin Pediatr Dent
December 2024
Department of Dental Research Cell, Dr D Y Patil Dental College and Hospital, Dr D Y Patil Vidyapeeth, Pune, Maharashtra, India.
Background: This systematic analysis of case reports aimed to compile available knowledge and identify trends in disorder onset, symptoms, treatment, and possible interventions across individual cases associated with Lesch-Nyhan syndrome (LNS) oral self-injury.
Materials And Methods: "Lesch-Nyhan syndrome" and "oral self-mutilation" were entered as keywords in four search engines. All cases reporting the patients' demographics and documented episodes of self-mutilation, with details on treatment and management, were included.
China CDC Wkly
January 2025
Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou City, Guangdong Province, China.
What Is Already Known About This Topic?: Human immunodeficiency virus (HIV) self-testing serves as a crucial strategy for overcoming testing barriers, with urine-based self-testing emerging as a potential novel approach.
What Is Added By This Report?: In a real-world setting, this study demonstrated that the urine rapid test exhibited lower diagnostic accuracy compared to the blood rapid test. Study participants expressed stronger preferences for HIV self-testing methods utilizing finger prick samples, accompanied by standard written instructions and lower costs.
Am J Case Rep
January 2025
Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan.
BACKGROUND Extensor pollicis longus (EPL) tendon rupture is a potential complication following distal radius fracture, typically occurring several weeks after injury. Herein, we present a rare case of acute extensor pollicis longus tendon rupture associated with a distal radius fracture. CASE REPORT A 35-year-old woman visited our hospital with a distal radius fracture.
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