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B Cells With Complementary B Cell Receptors Can Kill Each Other.
Eur J Immunol
January 2025
Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
B cells differentiate from hematopoietic stem cells in the bone marrow (BM) and migrate as transitional cells to the spleen where final maturation takes place. Due to the enormous diversity in variable (V) regions of B cell receptors for antigen (BCR), B cells with complementary BCRs are likely to be generated. These could encounter each other in the BM or in secondary lymphoid organs.
View Article and Find Full Text PDFNon-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
Clin Rev Allergy Immunol
December 2024
Univ. Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France.
Article Synopsis
- * Researchers measured the prevalence of IgG anti-IgA in PID patients compared to healthy controls and found a low percentage of PID patients with these antibodies and hypersensitivity.
- * The study suggests that complement activation might be a more significant factor in hypersensitivity reactions to immunoglobulin preparations, rather than just the presence of IgG anti-IgA.
Theories of immune recognition: Is anybody right?
Immunology
October 2024
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz and Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences since its original publication by Burnet. This gave origin to new paradigms that govern experimental immunology nowadays, such as the associative recognition of antigen model and the stranger/danger signal model.
View Article and Find Full Text PDFCellular and Molecular Immunity to Influenza Viruses and Vaccines.
Vaccines (Basel)
April 2024
Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Immune responses to influenza (flu) antigens reflect memory of prior infections or vaccinations, which might influence immunity to new flu antigens. Memory of past antigens has been termed "original antigenic sin" or, more recently, "immune imprinting" and "seniority". We have researched a comparison between the immune response to live flu infections and inactivated flu vaccinations.
View Article and Find Full Text PDFBiomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study.
Am J Respir Crit Care Med
August 2024
School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and National Institute for Health and Care Research Southampton Biomedical Research Centre, Southampton, United Kingdom.
The anti-IgE monoclonal antibody omalizumab is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during 1 year of omalizumab treatment. One-year open-label Study of Mechanisms of action of Omalizumab in Severe Asthma (SoMOSA) involving 216 patients with severe (Global Initiative for Asthma step 4/5) uncontrolled atopic asthma (at least two severe exacerbations in the previous year) taking high-dose inhaled corticosteroids and long-acting β-agonists with or without maintenance oral corticosteroids.
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