The aim of this study was to assess the variability of microbial risk associated with drinking water under various contaminant loading conditions in a drinking water source. For this purpose, a probabilistic-deterministic approach was applied to estimate the loadings of Cryptosporidium, Giardia, and Escherichia coli (E. coli) from fecal contamination sources during both dry and wet weather conditions. The relative importance of loads originating from various fecal contamination sources was also determined by a probabilistic approach. This study demonstrates that water resource recovery facilities were the dominant source of Giardia, yet rivers were more important with regards to Cryptosporidium. Estimated loadings were used as input to a three-dimensional hydrodynamic model of Lake Ontario; the fate and transport of microbial organisms were simulated at the influent of a drinking water intake. Discharge-based hydrodynamic modelling results were compared to observed concentrations. Simulated probability distributions of concentrations at the intake were used as an input to a quantitative microbial risk assessment (QMRA) model such that the variability of microbial risk in the context of drinking water could be examined. Depending on wind and currents, higher levels of fecal contamination reached the intake during wet weather loading scenarios. Probability distribution functions of Cryptosporidium, Giardia and E. coli concentrations at the intake were significantly higher during wet weather conditions when compared to dry conditions (p < 0.05). For all contaminants studied, the QMRA model showed a higher risk during wet weather (over 1 order of magnitude) compared to dry weather conditions. When considering sewage by-pass scenarios, risks remained below 2.7 × 10 person day for Giardia and E. coli O157:H7. Limited data were available for Cryptosporidium in by-pass effluents and the risk is unknown; hence it is critical to obtain reliable loading data for the riskiest scenarios, such as those associated with water resource recovery facility by-passes.
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http://dx.doi.org/10.1016/j.scitotenv.2019.07.373 | DOI Listing |
Front Microbiol
December 2024
School of Biosciences and Technology, Vellore Institute of Technology SBST, Vellore, Tamil Nadu, India.
The emergence and re-emergence of multi-drug-resistant (MDR) infectious diseases have once again posed a significant global health challenge, largely attributed to the development of bacterial resistance to conventional anti-microbial treatments. To mitigate the risk of drug resistance globally, both antibiotics and immunotherapy are essential. Antimicrobial peptides (AMPs), also referred to as host defense peptides (HDPs), present a promising therapeutic alternative for treating drug-resistant infections due to their various mechanisms of action, which encompass antimicrobial and immunomodulatory effects.
View Article and Find Full Text PDFFront Pediatr
December 2024
Department of Nutrition & Dietetics, School of Health Science & Education, Harokopio University, Athens, Greece.
Background: Early life infections (ELIs), encompassing both viral and bacterial types, occur within the first six months of life. Influenced by genetic host factors and environmental conditions, the relationship between ELIs and subsequent allergic manifestations, particularly cow's milk protein allergy (CMPA) and atopic dermatitis (AD), is complex and not fully understood.
Objective: The aim of the current study was to examine the potential interplay between nutrition, infections, and allergic manifestations in the first six months of life in infants with a family history of allergies, who were either exclusively breastfed (EBF) or fed a combination of breast milk and standard (SF) or partially hydrolyzed infant formula (pHF).
Food Chem X
January 2025
International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Different edible portions including meat (lump, claw and backfin) and roe of blue swimming crab () were analyzed. Both meat and roe had high protein content, but a greater fat content was found in roe. All meats showed higher levels of polyunsaturated fatty acids than roe.
View Article and Find Full Text PDFUrol Oncol
January 2025
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:
Complex relationships between the human microbiome and cancer are increasingly recognized for cancer sites that harbor commensal microbial communities such as the gut, genitourinary tract, and skin. For organ sites that likely do not contain commensal microbiota, there is still a substantial capacity for the human-associated microbiota to influence disease etiology across the cancer spectrum. We propose such a relationship for prostate cancer, the most commonly diagnosed cancer in males in the United States.
View Article and Find Full Text PDFEnviron Health Prev Med
January 2024
Department of Clinical Nutrition, Peking University Shenzhen Hospital.
Background: Depression substantially impacts on quality of life, personal relationships, and self-care. Gastrointestinal disorders are the common comorbidity of depression and 24.3% of patients with depression have disordered bowel habits.
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