There was agreement between the experimental results, obtained in the course of the Second UKEMS Collaborative Study, for the mutagenicity in Salmonella typhimurium of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline and the mutagenicity predicted by CASE (Computer Automated Structure Evaluation), a recently developed artificial intelligence system.
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Computer-automated prediction of the mutagenicity of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline: comparison with the results of the Second UKEMS Collaborative Study.
Mutagenesis
July 1986
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
There was agreement between the experimental results, obtained in the course of the Second UKEMS Collaborative Study, for the mutagenicity in Salmonella typhimurium of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline and the mutagenicity predicted by CASE (Computer Automated Structure Evaluation), a recently developed artificial intelligence system.
View Article and Find Full Text PDFPredicting the carcinogenicity of the aromatic amine derivatives tested in the second UKEMS Collaborative Study.
Mutagenesis
March 1986
Department of Environmental Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4"-diaminoterphenyl and 4-dimethylaminoazobenzene. CPBS predicted the non-carcinogenicity of 4-cyanodimethylaniline, a chemical of as yet unknown carcinogenicity.
View Article and Find Full Text PDFComparative activity of 4,4'-diaminobiphenyl (benzidine) and its terphenyl analogue, 4,4'-diaminoterphenyl, in two in vitro assays for potential carcinogenicity.
Carcinogenesis
September 1980
Imperial Chemical Industries Limited, Central Toxicology Laboratories, Macclesfield, Cheshire, UK.
The carcinogen 4,4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4,4''-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an understanding of the mechanism of action of benzidine as a carcinogen.
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