Evaluation of Risk Parameters in Bone Regeneration Using a Customized Titanium Mesh: Results of a Clinical Study.

Purpose: The aim of the study was an evaluation of risk factors for an innovative bone regeneration technique using a customized titanium mesh that was tested in a clinical setting.

Materials And Methods: This retrospective study included 65 patients with 70 grafting procedures of osseous defects of the jaws with a customized titanium mesh together with Advanced- and Injectable-Platelet-Rich Fibrin (A- and I-PRF), resorbable membranes, and bone grafting materials. Exposures of the meshes and grafting outcome were analyzed according to a novel classification as (a) punctual and (b) tooth width or complete exposure of the mesh (c). No exposure was stated as (d).

Results: In 37% of cases, exposures of the meshes occurred that were significantly associated with loss of grafted material (P < 0.001). Tobacco abuse (P = 0.032) and grafting procedures together with simultaneous sinus floor elevation techniques (P = 0.001) were found to be risk factors for success of the grafted material. Implant placement was not possible in 2 cases only.

Conclusion: The results of this study verified the treatment of large defects with a customized titanium mesh as a useful protocol with a predictable outcome, even in cases of dehiscences.