AI Article Synopsis
- Angiogenesis is crucial for the formation and maintenance of the corpus luteum, especially during early luteal development, which resembles a physiological injury accompanied by inflammation.
- Inflammatory responses involve various activated leukocytes, including macrophages, neutrophils, and eosinophils, which play significant roles in the process of neovascularization in luteal tissue.
- This review aims to explore how inflammatory factors contribute to angiogenesis and their mechanisms, enhancing the understanding of luteal function.
Article Abstract
Angiogenesis is a very important process that helps establish and maintain the normal structure and function of the corpus luteum (CL). Early luteal development can be considered a kind of physiological injury with an inflammatory response; therefore, the inflammatory response may play an important role in the luteal angiogenesis. The inflammatory response is companied by activated leukocytes and their mediators. For luteal tissue, numerous activated leukocytes such as macrophages, neutrophils and eosinophils are present in the early luteal phase and are widely involved in neovascularization. The objective of this review is to describe the role of the inflammatory factors in the angiogenesis and to discuss their mechanism. Knowledge of action and mechanism of these inflammatory factors on angiogenic activity will be beneficial for the understanding of luteal function.
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| http://dx.doi.org/10.1111/jog.14076 | DOI Listing |
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