AI Article Synopsis
- Auditory hypersensitivity is common in autism, and researchers suspect it may be linked to issues in the auditory brainstem.
- The study used autism model rats created through prenatal exposure to thalidomide to examine brain responses to sound.
- Results showed that these rats had an increased number of active neurons in the auditory region of the brain after sound exposure, indicating that prenatal thalidomide may disrupt normal auditory processing related to hypersensitivity in autism.
Article Abstract
Auditory hypersensitivity in autism is frequently observed in clinics. Dysfunction in the auditory brainstem has been suspected. We have established autism model rats using prenatal thalidomide exposure. Here we investigated whether abnormal response occurs in the brainstem following sound stimulus in autism model rats. Autism model rats were prepared by prenatal exposure to thalidomide on embryonic days 9 and 10 in pregnant rats. Then, the animals were exposed to 16-kHz pure tone auditory stimulus and c-Fos immunostaining was performed to examine the neuronal activity on postnatal day 49 to 51. Following sound stimulus, increased number of c-Fos-positive neurons was observed in the medial nucleus of the trapezoid body of autism model rats compared with the control rats. These results suggest that prenatal thalidomide might cause altered processing of auditory stimulus, leading to the characteristics of auditory hypersensitivity in autism.
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