Stochastic simulations data for figure 1 and the phase diagram construction for defining monotonic and non-monotonic regimes of the velocity as a function of .

We have compared our theoretical expressions of the normalized reaction velocities with that of simulation data points generated when the substrate fluctuations are present and absent, for the reaction schemes represented in Figure 1 Singh and Chaudhury, 2019 in the general monotonic as well as the conditional non-monotonic limit. We have also constructed the phase diagrams for the schemes given in Figure 1 Singh and Chaudhury, 2019 separating different regimes of the monotonic and the non-monotonic behaviors observed in the reaction rate.