Datasets of microarray analysis to identify -dependent interleukin-4-responsive genes in the mouse macrophage cell line RAW264.

Macrophages are classified mainly into two subtypes, M1 and M2, which exhibit distinct phenotypes, based on their microenvironment. We have recently demonstrated that is abundantly expressed in RAW264 macrophages, " is an orphan G-protein-coupled receptor associated with M2 macrophage polarization" (Islam et al., in press) [1]. Although recent studies have suggested that G-protein-coupled receptors (GPCRs) are associated with M1/M2 macrophage polarization ("G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonists reduce the production of proinflammatory cytokines and stabilize the alternative macrophage phenotype" (Hogenauer et al., 2014) [2], "Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models" (Sasaki et al., 2018) [3]), available information about GPCR-mediated macrophage polarization is still limited. This prompted us to generate -knockout (KO) RAW264 clones using the CRISPR/Cas9 genome editing system to elucidate the function of in interleukin (IL)-4-induced M2 macrophage polarization (Islam et al., in press) [1]. Here we present the datasets of a microarray analysis to identify -dependent IL-4-responsive genes in RAW264 cells. The raw microarray data are available in the Gene Expression Omnibus database (https://www.ncbi.nlm.nih.gov/geo/) under the accession number GSE117578, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117578.