Context: Psychological stress can be considered a risk factor for the initiation and progression of many pathological conditions, including type 1 and 2 diabetes mellitus and cancer.
Objectives: The aim of this review article was to evaluate the molecular and cellular mechanisms linking psychological stress to the onset and progression of diabetes and cancer.
Evidence Acquisition: The current review was conducted to survey and analyze studies related to the effects of psychological stress on diabetes and cancer.
Results: Psychological stress may make individuals prone to the development of diabetes through the impairment of the hypothalamic-pituitary-adrenal (HPA) axis function, sympathetic nerves system (SNS), lipid profile, cytokines balance, renin-angiotensin system (RAS), and insulin signaling pathway. Additionally, psychological stress can contribute to the development of cancer through the perturbation in the HPA axis, SNS function, and cytokines balance. Psychological stress is also capable of decreasing the levels of oxytocin and dopamine, leading to an increased risk of cancer in susceptible individuals.
Conclusions: It seems that psychological stress plays a significant role in the onset and progression of diabetes and cancer. The identification of the pathways triggered by psychological stress would open up a new avenue for the understanding of molecular mechanisms by which diabetes and cancer could be managed or even prevented.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628619 | PMC |
| http://dx.doi.org/10.5812/ijem.67400 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Daily Process of Interpersonal Conflict and Mood among Chinese Adolescents: A Multilevel Moderated Mediation Analysis of Cognitive Appraisal, Social Support and Psychological Capital.
Res Child Adolesc Psychopathol
January 2025
School of Developmental Psychology, Faculty of Psychology, Beijing Normal University, 19 Xinjiekouwai Avenue, Haidian District, Beijing, 100875, China.
A growing body of literature has confirmed the within-person process from interpersonal conflict to adolescent mood on a day-to-day timescale. However, research on how, when and for whom adolescent interpersonal conflict relates to their daily mood is underdeveloped. This study examined whether interpersonal conflict is related to mood through threat appraisal and self-blaming attribution and whether these relationships would be moderated by daily social support and psychological capital.
View Article and Find Full Text PDFStressors and Support Experienced by Active Duty U.S. Navy Sailors at Sea.
Mil Med
January 2025
San Diego State University School of Public Health, San Diego, CA 92182, USA.
Introduction: High occupational stress is generally associated with poorer mental health and reduced performance in military personnel, whereas access to support resources is associated with positive outcomes. However, little research has examined the unique stressors and supports experienced by sailors on ships while underway at sea. The objectives of this study were to (1) identify sailors' underway stressors and supports and (2) examine how these differ as a function of demographic and operational factors.
View Article and Find Full Text PDFComparison of Resilience Measures in Chinese Adolescents: Based on Item Response Theory.
J Pers Assess
January 2025
School of Psychology, Guizhou Normal University, Guiyang, China.
Resilience is an important ability that helps adolescents resist stress from everyday life. While resilience has been measured in many ways, no measures have been developed specifically for the adolescent population. This study analyzed three popular resilience questionnaires, evaluated their psychometric properties using item response theory and explored their applicability.
View Article and Find Full Text PDFRipple Effects of Early Life Stress on Vascular Health.
Hypertension
January 2025
Cardio-Renal Physiology and Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, AL (C.E.K., G.C.K., J.S.P.).
The term early life stress encompasses traumatic events occurring before the age of 18 years, such as physical abuse, verbal abuse, household dysfunctions, sexual abuse, childhood neglect, child maltreatment, and adverse childhood experiences. Adverse psychological experiences in early life are linked to enduring effects on mental and physical health in adulthood. In this review, we first describe the effects and potential mechanisms of early life stress on the components of the vasculature.
View Article and Find Full Text PDFProtocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study.
Wellcome Open Res
November 2024
Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, India.
Background: Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the effects of nutritional status, psychosocial adversities, and environmental pollutants on children's outcomes, little is known about their interaction and cumulative effects.
Objectives: This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children's cognitive development and mental health in urban and rural India.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!