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Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.
Clin Rev Allergy Immunol
June 2023
Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, piazzale Spedali Civili 1, Brescia, 25123, Italy.
Disease-specific autoantibodies are considered the most important biomarkers for systemic sclerosis (SSc), due to their ability to stratify patients with different severity and prognosis. Anti-nuclear antibodies (ANA), occurring in subjects with isolated Raynuad's phenomenon, are considered the strongest independent predictors of definite SSc and digital microvascular damage, as observed by nailfold videocapillaroscopy. ANA are present in more than 90% of SSc, but ANA negativity does not exclude SSc diagnosis: a little rate of SSc ANA negative exists and shows a distinct subtype of disease, with less vasculopathy, but more frequent lower gastrointestinal involvement and severe disease course.
View Article and Find Full Text PDFANA-negative Antitopoisomerase I Antibody Is Not Generally Accepted.
J Rheumatol
November 2019
Department of Laboratory Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Progression of nailfold microvascular damage and antinuclear antibody pattern in systemic sclerosis.
J Rheumatol
May 2013
Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Objective: This study evaluates possible correlations between the pattern of antinuclear antibodies (ANA) on indirect immunofluorescence (IIF) testing and nailfold microangiopathy stage (early, active, and late stage) in systemic sclerosis (SSc). Patients with SSc were followed prospectively to monitor progression of microvascular damage.
Methods: The ANA pattern on IIF was searched in 42 patients with SSc showing an early pattern of nailfold microangiopathy at baseline, and was followed using nailfold videocapillaroscopy (NVC) for a median time of 91 months.
The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis.
Br J Dermatol
March 2008
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
Background: Systemic sclerosis (SSc) is a connective tissue disorder with excessive fibrosis of the skin and various internal organs. Although SSc is a heterogeneous disease, it has been reported that the particular antinuclear antibodies (ANA) are often indicative of clinical features, disease course and overall severity.
Objective: To clarify the association of clinical and prognostic features with serum ANA in Japanese patients with SSc.
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