Insular epilepsy is underdiagnosed and accounts for a number of failed operations. Identifying insular target lesions on MR imaging can help guide intracranial electroencephalography and improve the outcome of surgery. In this study, we present a novel method of exploring the insular region for subtle lesions on 3D MR imaging by MPR postprocessing of slices in oblique reference planes. Using this method, we retrospectively reviewed presurgical MRIs that were initially considered to have normal findings in 7 pediatric patients with intractable insular epilepsy. Insular epilepsy was confirmed in these patients on stereo-electroencephalography and histopathology. The MPR postprocessing method we describe helped detect subtle insular lesions in all 7 patients.
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http://dx.doi.org/10.3174/ajnr.A6143 | DOI Listing |
Front Neurol
January 2025
Department of Neurosurgery and Neurotechnology, Eberhard Karls University, Tübingen, Germany.
Objective: Epilepsy is considered as a network disorder of interacting brain regions. The propagation of local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines the semiology of seizures. However, in highly interconnected brain regions such as the insula, the association between the SOZ and semiology is blurred necessitating invasive stereoelectroencephalography (SEEG).
View Article and Find Full Text PDFEpilepsy Behav
January 2025
Epileptology Unit Reference Center for Rare Epilepsies Department of Neurology AP-HP Pitié-Salpêtrière Hospital Paris France; Rehabilitation Unit AP-HP Pitié-Salpêtrière Hospital Paris France; Paris Brain Institute (ICM), Sorbonne-Université, Inserm U1127, CNRS 7225, Paris F-75013 France; Université Paris Sorbonne, Paris, France. Electronic address:
This narrative review aims to identify and summarize existing research to better understand the pathophysiological and neuroanatomical bases of social cognition deficits in people with epilepsy. The neuroanatomical basis of social cognition was primarily examined in healthy subjects. In healthy individuals, social cognition is supported by a complex network of interconnected brain regions.
View Article and Find Full Text PDFNeurophysiol Clin
January 2025
Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK; Department of Neurosurgery, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK.
Objectives: Computer-assisted planning (CAP) allows faster SEEG planning and improves grey matter sampling, orthogonal drilling angles to the skull, reduces risk scores and minimises intracerebral electrode length. Incorporating prior SEEG trajectories enhances CAP planning, refining output with centre-specific practices. This study significantly expands on the previous work, compares priors libraries between two centres, and describes differences between SEEG in adults and children in these centres.
View Article and Find Full Text PDFClin Neurophysiol
December 2024
Unidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Laboratorio de Anatomía Viviente, 3ra Cátedra de Anatomía Normal, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Objective: To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task.
Methods: Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis.
Neurol Sci
December 2024
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510000, China.
We aimed to define the clinical features and outcomes of encephalitis associated with anti-GAD65 Abs. In addition, we reviewed cases published in the literature with GAD65 encephalitis. We retrospectively studied 482 consecutive patients attending a tertiary care center for evaluation of an autoimmune neurological disorder.
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