Serine-Glycine-One-Carbon Metabolism: The Hidden Achilles Heel of -Amplified Neuroblastoma?

In this issue of , Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC biosynthetic pathway in -amplified cells. Furthermore, inhibition of serine synthesis generates metabolic stress in -amplified neuroblastoma cells, causing cell-cycle arrest and autophagy. Together, these data suggest that the SGOC pathway is an attractive therapy target in neuroblastoma..