The Proposed Specifiers for Conduct Disorder (PSCD) scale (Salekin & Hare, 2016) was developed as a measure of the broader construct of psychopathy in childhood and adolescence. In addition to conduct disorder (CD) symptoms, the PSCD addresses the interpersonal (grandiose-manipulative), affective (callous-unemotional), and lifestyle (daring-impulsive) traits of psychopathic personality. The PSCD can be scored by parents and teachers. The present study is a preliminary test of the psychometric properties of the PSCD-Parent Version in a sample of 2,229 children aged 3 to 6 years. Confirmatory factor analyses supported both a 3- and 4-factor structure being invariant across gender groups. The validity of the PSCD was also supported by convergent-divergent associations with an alternative measure of psychopathic traits as well as by the expected relations with fearlessness, conduct problems, reactive and proactive aggression, attention-deficit hyperactivity disorder and oppositional defiant disorder symptoms, and social competence skills. Overall, the PSCD is a promising alternative measure for assessing early manifestation of the broader construct of psychopathy in children. Its use should facilitate discussion of the conceptualization, assessment, predictive value, and clinical usefulness of the psychopathic construct as it relates to CD at early developmental stages. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Unlabelled: It is currently estimated that every 15 minutes an infant is born with opioid use disorder and undergoes intense early life trauma due to opioid withdrawal. Clinical research on the long-term consequences of gestational opioid exposure reports increased rates of social, conduct, and emotional disorders in these children. Here, we investigate the impact of perinatal opioid exposure (POE) on behaviors associated with anhedonia and stress in male and female Sprague Dawley rats.
View Article and Find Full Text PDFNeurobiol Stress
January 2025
Department of Translational Neuroscience, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
With the recent rise in the rate of alcohol use disorder (AUD) in women, the historical gap between men and women living with this condition is narrowing. While there are many commonalities in how men and women are impacted by AUD, an accumulating body of evidence is revealing sex-dependent adaptations that may require distinct therapeutic approaches. Preclinical rodent studies are beginning to shed light on sex differences in the effects of chronic alcohol exposure on synaptic activity in a number of brain regions.
View Article and Find Full Text PDFSchizophr Bull
January 2025
Orygen, Parkville, Victoria 3052, Australia.
Background: Although attention deficit hyperactivity disorder (ADHD) is known to be common in psychotic disorders, reported prevalence rates vary widely, with limited understanding of how different factors (eg, assessment methods, geographical region) may be associated with this variation. The aim was to conduct a systematic review and meta-analysis to determine the prevalence of ADHD in psychotic disorders and factors associated with the variability in reported rates.
Study Design: Searches were conducted in MEDLINE, Embase, PsycINFO, CINAHL, and Scopus in May 2023.
Neurosciences (Riyadh)
January 2025
From the Neurology of Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Marchiafava-Bignami disease (MBD) is a rare neurological disorder typically occurring in alcoholic patients. The main disease mechanism is hypothesized to be vitamin B-complex deficiency due to malnutrition. In the literature, there have been few reported cases of the disease occurring in patients who have undergone bariatric surgery.
View Article and Find Full Text PDFMol Psychiatry
January 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing (16S) and shallow shotgun sequencing (WGS) were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and Neurocomputational Mechanisms of Affiliation and Personality Study Center for Biomedical Research Excellence (NeuroMAP CoBRE) cohorts.
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