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Genetic Testing in the Diagnosis and Biology of Acute Leukemia. | LitMetric

Genetic Testing in the Diagnosis and Biology of Acute Leukemia.

Am J Clin Pathol

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis.

Published: August 2019

AI Article Synopsis

  • A workshop in 2017 focused on how molecular genetics plays a key role in diagnosing and understanding acute leukemia cases.
  • Two sessions reviewed a total of 94 cases, including various types of acute leukemia, showcasing important genetic changes that affect diagnosis, treatment, and knowledge of the disease.
  • The findings stress the need for a comprehensive approach that combines genetic, clinical, and other diagnostic information to effectively tackle the complexities of acute leukemia.

Article Abstract

Objectives: The 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology examined the role of molecular genetics in the diagnosis and biology of acute leukemia.

Methods: Acute leukemias were reviewed in two sessions: "Genetic Testing in Diagnosis of Acute Leukemias" (53 cases) and "Genetics Revealing the Biology of Acute Leukemias" (41 cases).

Results: Cases included acute lymphoblastic leukemia, acute myeloid leukemia, and acute leukemia of ambiguous lineage. Many cases demonstrated genetic alterations of known diagnostic, prognostic, and/or therapeutic significance, while others exhibited alterations that illuminated disease biology. The workshop highlighted the complexity of acute leukemia diagnosis and follow-up, while illustrating advantages and pitfalls of molecular genetic testing.

Conclusions: Our understanding of the molecular genetics of acute leukemias continues to grow rapidly. Awareness of the potential complexity of genetic architecture and environment is critical and emphasizes the importance of integrating clinical information with morphologic, immunophenotypic, and molecular genetic evaluation.

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Source
http://dx.doi.org/10.1093/ajcp/aqz093DOI Listing

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