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Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.
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Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease primarily affecting very preterm infants. NEC is characterized by excessive inflammation and ischemia in the intestines, and is associated with prolonged, severe visceral pain. Despite its recognition as a highly painful disease, current pain management for NEC is often inadequate, and research on optimal analgesic therapy for these patients is lacking.
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Department of Psycho-cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
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View Article and Find Full Text PDFGastrodin protects against sepsis-associated encephalopathy by suppressing ferroptosis.
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Department of Pathology and Pathophysiology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, Yunnan, China.
Background: Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, substantially elevating both mortality and healthcare costs for patients. Gastrodin (GAS), a principal bioactive constituent of Gastrodia elata Blume, is neuroprotective in various neurological disorders, including ischemic stroke, epilepsy, Alzheimer's disease, and neuropathic pain. In this study, we sought to investigate whether GAS could serve as a protective agent against SAE.
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View Article and Find Full Text PDF[Clinical analysis of Tolosa-Hunt syndrome].
Zhonghua Yan Ke Za Zhi
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Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin300052, China.
Article Synopsis
- The study analyzed clinical features of Tolosa-Hunt syndrome (THS), a type of painful ophthalmoplegia, by collecting data from patients diagnosed at a hospital over four years.
- A total of 35 patients were included, with 18 diagnosed with THS, who typically presented symptoms like pain, ptosis, and MRI abnormalities, alongside various immunological findings.
- Treated with glucocorticoids, most THS patients saw symptom relief within weeks, though some experienced relapses during follow-up.
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