AI Article Synopsis
- - The study focused on using the chiral structure of the antibiotic vancomycin to create a new type of hybrid catalyst based on iridium (IrCp*).
- - Various analytical methods, including MALDI-TOF and NMR, confirmed that vancomycin successfully coordinates with iridium to form this hybrid system.
- - The resulting catalyst was effective in the Asymmetric Transfer Hydrogenation of cyclic imines, achieving a 61% yield in reducing quinaldine and demonstrating saturation kinetics with an efficiency value of K/K = 0.688 hmM.
Article Abstract
The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines allowing to obtain a valuable 61% () in the asymmetric reduction of quinaldine . The catalytic system exhibited a saturation kinetics with a calculated efficiency of K/K = 0.688 hmM.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695689 | PMC |
| http://dx.doi.org/10.3390/molecules24152771 | DOI Listing |
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