, syn. , is a tree growing in West Africa and is used in traditional medicine against a variety of diseases, including malaria. In the work reported here, root bark and stem bark extracts of this tree, as well as compounds isolated from the extracts, have been investigated for activity against chloroquine-sensitive and chloroquine-resistant strains of . In addition, toxicity against nauplii of the brine shrimp has been studied. Dichloromethane extracts of the root bark and stem bark, and a methanol extract of the stem bark, showed anti-parasitic activity towards chloroquine-sensitive as well as chloroquine-resistant , with IC values between 1 and 10 µg/mL. Among the isolated compounds, bis-dihydrochelerythrinyl ether, buesgenine, chelerythrine, -fagarine, skimmianine, and pellitorine were the most active, with IC values of less than 5 µg/mL. The dichloromethane extracts were toxic to brine shrimp nauplii, with LC values of less than 1 µg/mL. Methanol extracts were much less toxic (LC between 50 and 100 µg/mL). Among the isolated substances, bis-dihydrochelethrinyl ether was the most toxic (LC ca. 2 µg/mL).
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http://dx.doi.org/10.1055/a-0973-0067 | DOI Listing |
Trans R Soc Trop Med Hyg
January 2025
Department of Biology, Chemistry and Physics, Faculty of Health, Natural Resources and Applied Sciences, Namibia University of Science and Technology, Private Bag 13388, 13 Jackson Kaujeua Street Windhoek, Windhoek, Namibia.
Background: Despite Naja nigricincta nigricincta being responsible for most snake envenomation in remote Namibian regions, an effective intervention against its venom remains undiscovered. This study aimed to scientifically validate Namibian folklore claims about Senegalia mellifera extract's efficacy against snake envenomation.
Methods: In vitro assays were conducted to assess the inhibitory potential of S.
Arch Razi Inst
June 2024
School of Life Science, Central University of Karnataka, kalaburagi-585367, Karnataka, India.
Nature is a valuable resource, supplying remedies for the treatment of all diseases. Plant kingdom stands for a plethora of natural compounds that are well known for their utilization in therapeutic applications. They may pave the way for the development of new mediators with appropriate efficacy in many pathological disorders in the future.
View Article and Find Full Text PDF<i>Ormocarpum trichocarpum</i> (Taub.) Engl. is a shrub or small tree harvested from the wild as a source of food, traditional medicines and wood.
View Article and Find Full Text PDFPlant Dis
December 2024
Chinese Academy of Sciences, South China Botanical Garden, Guangzhou, Guangdong, China;
Litsea cubeba (Lour.) Per., named as May Cang, is a rare deciduous evergreen tree and cultivated for its ethnopharmacological properties and medicinal uses.
View Article and Find Full Text PDFFront Plant Sci
December 2024
Departamento de Ciencias de la Vida, Facultad de Ciencias, Universidad de Alcalá, Madrid, Spain.
Alders are widely distributed riparian trees in Europe, North Africa and Western Asia. Recently, a strong reduction of alder stands has been detected in Europe due to infection by species (Stramenopila kingdom). This infection causes a disease known as alder dieback, characterized by leaf yellowing, dieback of branches, increased fruit production, and bark necrosis in the collar and basal part of the stem.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!