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The Beginning of a "Regulatory Renaissance": Positioning Regulatory Coverage at the Interface of Human Expertise and Digital Support.
Ther Innov Regul Sci
March 2025
U.S. Food and Drug Administration, White Oak Campus 10903 New Hampshire Ave, Silver Spring, Maryland, MD, 20993, USA.
Following the largest reorganization in its history, the U.S. Food and Drug Administration (FDA) is now working to modernize how it defines and engages in regulatory oversight of the quality of products that the agency regulates.
View Article and Find Full Text PDFProposal of novel Predicted No Effect Concentrations (PNEC) for metals in freshwater using Species Sensitivity Distribution for different taxonomic groups.
Sci Rep
March 2025
Research Group on Environmental Applications of Advanced Oxidation Processes, Department of Sanitary and Environmental Engineering, The Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Water pollution by metals and metalloids promotes toxic effects to aquatic biota especially in mining regions. Environmental legislation applied to protect aquatic life from the toxicity of metals relies on the definition of protective values (PVs) for each compound. Among methods used to define PVs, Species Sensitivity Distribution (SSD) curves enable the derivation of the Predicted No Effect concentration (PNEC).
View Article and Find Full Text PDFTowards an inclusive and culturally sensitive conceptualisation of sexual well-being of young people: preliminary framework development using a modified Delphi methodology.
Sex Reprod Health Matters
March 2025
Associate Professor, Institute for Family and Sexuality Studies, Department of Neurosciences, Faculty of Medicine, KU Leuven, Leuven, Belgium,
This study aims to contribute to the development of a comprehensive framework for sexual well-being of young people. By making space for diverse young people's perspectives through co-creating the framework, we seek to enhance the understanding of sexual well-being in sexual and reproductive health and rights (SRHR) research in a culturally sensitive and inclusive way. A modified Delphi study invited SRHR young professionals (aged 18-30) with different backgrounds to participate as experts in three rounds of online discussions.
View Article and Find Full Text PDFSPAC-Net: Rethinking Point Cloud Completion with Structural Prior.
IEEE Trans Vis Comput Graph
November 2024
Point cloud completion aims to infer a complete shape from its partial observation. Many approaches utilize a pure encoderdecoder paradigm in which complete shape can be directly predicted by shape priors learned from partial scans, however, these methods suffer from the loss of details inevitably due to the feature abstraction issues. In this paper, we propose a novel framework, termed SPAC-Net, that aims to rethink the completion task under the guidance of a new structural prior, we call it interface.
View Article and Find Full Text PDFRe-thinking "non-response" to wasting treatment: Exploratory analysis from 14 studies.
PLOS Glob Public Health
February 2025
Emergency Nutrition Network, Oxford, United Kingdom.
Children who receive therapeutic feeding for wasting treatment but do not reach the anthropometric definitions of recovery (usually within 12-16 weeks) are categorised as 'non-responders' and considered as treatment failures. We conducted a pooled analysis to explore the growth trajectories of non-responders and the appropriateness of the definition of 'non-response'. We pooled 14 studies of children aged 6-59 months receiving treatment for wasting.
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