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Concurrent Zoster Sine Herpete and Hepatosplenic Fungal Infection in a Cancer Patient: A Case Report.
Cureus
October 2024
Infectious Diseases and Tropical Medicine, Moffitt Cancer Center, Tampa, USA.
In patients undergoing treatment for hematological cancers, like hairy cell leukemia (HCL), appropriate management of infections is of utmost importance. This paper describes the successful treatment of an HCL patient who had both visceral zoster sine herpete (ZSH) and hepatosplenic fungal infection, possibly caused by . To our knowledge, this is the first such case to appear in the literature, as these are rare conditions associated with states of immunosuppression, similar to those observed in hematological malignancy.
View Article and Find Full Text PDFMaculopapular rash with multiple drug hypersensitivity to cotrimoxazole, amikacin, piperacillin/tazobactam, and meropenem in a patient with hairy cell leukemia.
Allergol Select
July 2024
Department of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust.
We describe a rare case of a 54-year-old female with hairy cell leukemia, who following treatment for neutropenic sepsis, developed an extensive severe maculopapular exanthema with perifollicular hemorrhage. Cladribine, cotrimoxazole, allopurinol, domperidone, amikacin, piperacillin/tazobactam, and meropenem had all been given in the 9 days prior to eruption onset. Three months later, drug patch testing/delayed intradermal testing was positive to cotrimoxazole, trimethoprim, amikacin, piperacillin/tazobactam, and meropenem, with additional evidence of penicillin cross-reactivity.
View Article and Find Full Text PDFConcomitantly Diagnosed Disseminated Infection and Hairy Cell Leukemia With Review of Pathophysiology.
J Investig Med High Impact Case Rep
May 2024
Article Synopsis
- This text discusses a case of a 31-year-old man simultaneously diagnosed with Hairy Cell Leukemia (HCL) and a severe non-tuberculous mycobacterial infection, noting that the exact causes of this association are still unknown.
- The patient presented symptoms like rash, low blood cell counts, and swollen lymph nodes, with both HCL and the infection diagnosed through advanced medical testing.
- Despite successful chemotherapy for HCL, the infection persisted for six months before being effectively treated with a combination of antibiotics, underscoring the need for more research into the relationship between HCL and these types of infections for better management in the future.
Erdheim-Chester disease as complex clinical presentation and diagnosis: A case report and concise review of literature.
Medicine (Baltimore)
April 2024
Department of Health Promotion, Maternal and Child Health, Internal and Specialized Medicine of Excellence "G. D. Alessandro" (PROMISE), University of Palermo, Palermo, Italy.
Rationale: Erdheim-Chester disease (ECD) is a rare multisystemic disease characterized by the infiltration of multiple organs by foamy CD68 + CD1a-histiocytes. The genetic background consists of gain-of-function somatic mutations in the mitogen-activated protein kinase pathway. The purpose of the present paper is to make a contribution to the scientific literature on ECD by reporting our experience with a complex clinical case report, along with a concise review of the literature.
View Article and Find Full Text PDFSimultaneous blastic plasmacytoid dendritic cell neoplasm and myelofibrosis: A case report.
Oncol Lett
May 2024
Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China.
Article Synopsis
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive cancer often linked to other blood disorders, specifically myelofibrosis (MF) in this case.
- A 70-year-old male presented with a large purplish-red rash and was diagnosed with BPDCN through biopsy and genetic tests.
- Despite receiving one cycle of chemoimmunotherapy, the patient's condition worsened, resulting in an infection and ultimately his death, highlighting the severe prognosis and the need for increased awareness of BPDCN among medical professionals.
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