Purpose: We analyzed the role of oxidative stress in detrusor overactivity (DO) by measuring serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), and arylesterase.
Materials And Methods: The study included 38 female patients diagnosed with DO and 29 healthy female subjects forming the control group. Serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), and arylesterase were analyzed. The results of serum TAC, TOS, IMA, AOPP, PON, and arylesterase of the subjects in both groups were compared.
Results: There was no difference between the groups in terms of age. When compared to the control group, serum TAC and IMA levels were statisticaly lower (P < 0,001) and higher (P = 0,003), respectively. However, TOS, AOPP, PON, arylesterase levels were similar in both groups ( p > 0.05 ).
Conclusion: There seems to be an association between DO and oxidative damage according to our results, this can be measured by analyzing TAC and IMA in this patient group.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.22037/uj.v0i0.5090 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pesticide Exposure and Its Association with Parkinson's Disease: A Case-Control Analysis.
Cell Mol Neurobiol
November 2024
Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Parkinson's disease (PD) is a complex disorder that arises from genetic and environmental factors. The current investigation endeavors to investigate the role of exposure to organochlorine (OCPs) and organophosphate pesticides (OPPs), recognized as the main environmental elements, in the genesis of PD. In this case-control study, 29 PD patients and 51 healthy subjects were involved.
View Article and Find Full Text PDFDisease response in rheumatoid arthritis across four biologic therapies associates with improvement in paraoxonase-1 activity and oxylipins.
RMD Open
October 2024
Department of Medicine, Division of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.
Objective: Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme, that has been implicated as a biomarker of cardiovascular risk in patients with rheumatoid arthritis (RA). We aimed to investigate how different biologic therapies affect levels of PON1 and oxylipins.
Methods: 1213 adult patients with RA in the Comparative Effectiveness Registry to study Therapies for Arthritis and Inflammatory CoNditions cohort study with moderate-to-high disease activity (Clinical Disease Activity Index (CDAI) >10) who initiated a new biologic (tocilizumab (TCZ), n=296; abatacept, n=374; tumour necrosis factor inhibitors, n=427; rituximab, n=116) were followed prospectively with serum specimens analysed for PON1 activity by arylesterase (ARYL), lactonase (LAC) and PON assays at baseline and after 6 months of biologic therapy.
Comparative study of oxidative stress in cancer patients occupationally exposed to the mixture of pesticides.
Discov Oncol
October 2024
Department of Biotechnology, DDU Gorakhpur University, Gorakhpur, India.
Article Synopsis
- Cancer caused nearly 10 million deaths globally in 2020, and studies suggest a link between pesticide exposure and cancer development.
- The study measured oxidative stress markers in the serum of cancer patients exposed to pesticides and those unexposed, finding decreased enzyme activity and increased homocysteine levels in both groups.
- While there were no significant differences between the two cancer groups, the results indicate oxidative stress's role in cancer development, with a call for further research on homocysteine as a potential disease marker.
Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients.
Turk Neurosurg
July 2024
Balikesir University, Faculty of Medicine, Department of Neurosurgery, Balikesir, Türkiye.
Aim: To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.
Material And Methods: This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities.
Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease.
Chem Biol Interact
January 2024
Department of Life Sciences and Biotechnology and LTTA Centre, University of Ferrara, Italy; Psychiatric Department, School of Medicine, University of Maryland, Baltimore MD, USA. Electronic address:
Paraoxonase (PON) enzymes (PON1, PON2 and PON3) exert antioxidant properties through arylesterase, lactonase and paraoxonase activities. Increasing findings suggested their potential involvement, particularly PON1 and PON2, in Alzheimer's disease (AD), a neurodegenerative pathology characterized by early oxidative stress. Specifically, decreased serum PON1-arylesterase and lactonase activities seem to be associated with an increased brain oxidative damage in early AD, leading to hypothesize that PON activity alterations might be an early event in AD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!