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Antibiotic prophylaxis practice in gastrointestinal surgery in five hospitals in southern Benin.
Infect Prev Pract
December 2024
Clinical Pharmacy and Pharmacoepidemiology research group (CLIP), Louvain Drug Research Institute (LDRI), Université catholique de Louvain, Brussels, Belgium.
Background: Benin's healthcare system is characterized by a lack of local guidelines for surgical antibiotic prophylaxis (SAP), which is essential to prevent surgical site infection.
Aim: To audit compliance for SAP practices in gastrointestinal surgery.
Methods: Data were prospectively collected from gastrointestinal surgery departments in five hospitals.
Development of a Medication-Use Evaluation Template for Andexanet Alfa in the Reversal of Anticoagulation With Factor Xa Inhibitors.
J Pharm Pract
February 2025
North American Thrombosis Forum, Brookline, MA, USA.
Medication-use evaluations are meant to ensure that medication-use processes are consistent with prevailing standards of care, assure optimal use of therapy, and reduce the risk of medication-related problems. Reversal agents for direct oral anticoagulants are a worthy focus for medication-use evaluations for reasons of efficacy, safety, and cost. A multidisciplinary team of experts developed 2 medication-use evaluation templates illustrating the application of professional society guidelines to the appropriate use of andexanet alfa.
View Article and Find Full Text PDFAntibiotic stewardship in the emergency department setting: Focus on oral antibiotic selection for adults with skin and soft tissue infections.
Am J Health Syst Pharm
October 2024
Department of Veterans Affairs, Hines, IL, USA.
Purpose: An advisory panel of experts was convened by the ASHP Foundation as a part of its Medication-Use Evaluation Resources initiative to provide commentary on an approach to antibiotic stewardship in the treatment of skin and soft tissue infections (SSTIs), with a focus on oral antibiotics in the emergency department (ED) setting for patients who will be treated as outpatients. Considerations include a need to update existing guidelines to reflect new antibiotics and susceptibility patterns, patient-specific criteria impacting antibiotic selection, and logistics unique to the ED setting.
Summary: While national guidelines serve as the gold standard on which to base SSTI treatment decisions, our advisory panel stressed that institutional guidelines must be regularly updated and grounded in local antimicrobial resistance patterns, patient-specific factors, and logistical considerations.
When Antimicrobial Treatment and Surgical Prophylaxis Collide: A Stewardship Opportunity.
Hosp Pharm
August 2024
Department of Medicine, Wellington Regional Medical Center, Wellington, FL, USA.
In 2002, the Centers for Medicare and Medicaid Services (CMS) in collaboration with the Centers for Disease Control and Prevention (CDC) established the (SIP) project for the purposes of developing and standardizing quality improvement measures known to reduce the rates of post-operative surgical site infections (SSIs). Four years later the (SCIP), an expansion of SIP, was published in governmental provided several additional initiatives applicable to the perioperative period. Central to both projects are the assurance of the timeliness, selection, and duration of peri-operative surgical prophylactic antibiotics.
View Article and Find Full Text PDFEvaluation of the appropriateness of vancomycin therapeutic drug monitoring in the intensive care unit with a clinical pharmacy approach, a cross-sectional study.
Eur J Hosp Pharm
June 2024
Clinical Pharmacy Department, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey
Objectives: Vancomycin, a glycopeptide antibiotic has antibacterial activity against Gram-positive bacteria and is frequently used in the intensive care unit (ICU). Inappropriate therapeutic drug monitoring (TDM) of vancomycin is a common problem encountered in hospital daily practice. The aim of this study was to evaluate the appropriateness of vancomycin trough-guided TDM in patients treated in the ICU using a clinical pharmacy approach.
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