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Exploring the Intersection of E-commerce and Healthcare: A Visual Analysis of Research Trends.
Cureus
September 2024
Department of Computer Applications, Marian College Kuttikkanam (Autonomous), Kuttikkanam, IND.
The role of e-commerce in healthcare is one of the key research areas emerging from the broader digital transformation of health services and consumer interactions. This study presents the bibliometric analysis of literature on e-commerce in healthcare based on publications from 1993 to 2024 in Scopus. In particular, this analysis shows trends in the publication record that have been constantly growing, with prominent increases during the COVID-19 pandemic, now hardwiring the fact that digital technologies are key in promoting global health.
View Article and Find Full Text PDFNetrin signaling mediates survival of dormant epithelial ovarian cancer cells.
Elife
July 2024
London Regional Cancer Program, London Health Sciences Centre Research Institute, London, Canada.
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension culture model of high-grade serous ovarian cancer (HGSOC) dormancy and devised a novel CRISPR screening approach to identify survival genes in this context.
View Article and Find Full Text PDFImmune evasion: An imperative and consequence of MYC deregulation.
Mol Oncol
October 2024
Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.
MYC has been implicated in the pathogenesis of a wide range of human tumors and has been described for many years as a transcription factor that regulates genes with pleiotropic functions to promote tumorigenic growth. However, despite extensive efforts to identify specific target genes of MYC that alone could be responsible for promoting tumorigenesis, the field is yet to reach a consensus whether this is the crucial function of MYC. Recent work shifts the view on MYC's function from being a gene-specific transcription factor to an essential stress resilience factor.
View Article and Find Full Text PDFThe ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens.
Mol Psychiatry
November 2024
Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because the connection between pleasure and drug use becomes hard-wired in the nucleus accumbens (NAc), which interfaces motivation, effective therapies need to modulate this mesolimbic reward system. Here, we report that mice with knockdown of the cation channel TRPA1 (transient receptor potential ankyrin 1) were resistant to the drug-seeking behavior and reward effects of cocaine compared to their wildtype litter mates.
View Article and Find Full Text PDFThe Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer.
Gastroenterology
December 2024
Department of Pathology, University of Chicago, Chicago, Illinois; Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, Illinois; Committee on Cancer Biology, University of Chicago, Chicago, Illinois. Electronic address:
Present in all eukaryotic cells, the integrated stress response (ISR) is a highly coordinated signaling network that controls cellular behavior, metabolism, and survival in response to diverse stresses. The ISR is initiated when any 1 of 4 stress-sensing kinases (protein kinase R-like endoplasmic reticulum kinase [PERK], general control non-derepressible 2 [GCN2], double-stranded RNA-dependent protein kinase [PKR], heme-regulated eukaryotic translation initiation factor 2α kinase [HRI]) becomes activated to phosphorylate the protein translation initiation factor eukaryotic translation initiation factor 2α (eIF2α), shifting gene expression toward a comprehensive rewiring of cellular machinery to promote adaptation. Although the ISR has been shown to play an important role in the homeostasis of multiple tissues, evidence suggests that it is particularly crucial for the development and ongoing health of the pancreas.
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