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AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.
PLoS Comput Biol
November 2024
Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany.
Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a central challenge in developmental biology, particularly in early mammalian development, where tissue-level differentiation arises from seemingly cell-autonomous mechanisms. In this study, we present a multi-scale, spatial-stochastic simulation framework for mouse embryogenesis, focusing on inner cell mass (ICM) differentiation into epiblast (EPI) and primitive endoderm (PRE) at the blastocyst stage. Our framework models key regulatory and tissue-scale interactions in a biophysically realistic fashion, capturing the inherent stochasticity of intracellular gene expression and intercellular signaling, while efficiently simulating these processes by advancing event-driven simulation techniques.
View Article and Find Full Text PDFCataract surgery with endothelial keratoplasty.
Curr Opin Ophthalmol
January 2025
Cornea, External Eye Diseases and Refractive Surgery Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Article Synopsis
- This review focuses on the combined approach of cataract surgery with endothelial keratoplasty (EK), emphasizing key factors such as intraocular lens (IOL) selection and surgical technique.
- Recent advancements in imaging have enhanced the detection of corneal edema, which is crucial for effective surgical decision-making regarding EK methods.
- The review highlights that both sequential and triple-EK can achieve similar vision outcomes, but they differ in recovery time and complication rates, with careful preoperative planning being essential for optimal patient results.
Causal definitions versus casual estimation: Reply to Valente et al. (2022).
Psychol Methods
June 2024
Methods Center, University of Tübingen.
In this response to Valente et al. (2022), I am discussing the plausibility and applicability of the proposed mediation model and its causal effects estimation for single case experimental designs (SCEDs). I will focus on the underlying assumptions that the authors use to identify the causal effects.
View Article and Find Full Text PDFBridging the gap between subjective probability and probability judgments: The quantum sequential sampler.
Psychol Rev
September 2024
Department of Psychology, City, University of London.
One of the most important challenges in decision theory has been how to reconcile the normative expectations from Bayesian theory with the apparent fallacies that are common in probabilistic reasoning. Recently, Bayesian models have been driven by the insight that apparent fallacies are due to sampling errors or biases in estimating (Bayesian) probabilities. An alternative way to explain apparent fallacies is by invoking different probability rules, specifically the probability rules from quantum theory.
View Article and Find Full Text PDFChildren's limited tooling ability in a novel concurrent tool use task supports the innovation gap.
Sci Rep
September 2024
School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Article Synopsis
- School-aged kids often struggle to come up with new ways to use tools, even though they can learn from others.
- Researchers believe this is harder when tasks involve using two tools at the same time rather than one after the other.
- In a study, even the oldest kids had a tough time with the harder tasks, showing that using tools correctly gets harder when there are more complicated steps involved.
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