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C-reactive protein as a possible indicator of PTSD prognosis and comorbid anhedonia.
Brain Behav Immun
January 2025
National Center for PTSD at VA Boston Healthcare System, USA; Boston University Chobanian & Avedisian School of Medicine, Department of Psychiatry, USA. Electronic address:
Posttraumatic stress disorder (PTSD) is often chronic, which is costly to the individual and society. Easy-to-measure prognostic indicators can help to ensure that those with the greatest symptoms receive treatment. Inflammatory biomarkers may precede and predict depression chronicity and worsening, as well as PTSD.
View Article and Find Full Text PDFDifferential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.
Sci Rep
January 2025
Department of Psychiatry, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Childhood abuse represents one of the most potent risk factors for the development of psychopathology during childhood, accounting for 30-60% of the risk for onset. While previous studies have separately associated reductions in gray matter volume (GMV) with childhood abuse and internalizing psychopathology (IP), it is unclear whether abuse and IP differ in their structural abnormalities, and which GMV features are related to abuse and IP at the individual level. In a pooled multisite, multi-investigator sample, 246 child and adolescent females between the ages of 8-18 were recruited into studies of interpersonal violence (IPV) and/or IP (i.
View Article and Find Full Text PDFCuration and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program.
J Alzheimers Dis
December 2024
National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA.
Background: The age distribution and diversity of the VA Million Veteran Program (MVP) cohort make it a valuable resource for studying the genetics of Alzheimer's disease (AD) and related dementias (ADRD).
Objective: We present and evaluate the performance of several International Classification of Diseases (ICD) code-based classification algorithms for AD, ADRD, and dementia for use in MVP genetic studies and other studies using VA electronic medical record (EMR) data. These were benchmarked relative to existing ICD algorithms and AD-medication-identified cases.
Neural activity during working memory predicts clinical response to computerized executive function training prior to cognitive processing therapy.
Psychol Med
December 2024
Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
Background: Executive dysfunction, including working memory deficits, is prominent in posttraumatic stress disorder (PTSD) and can impede treatment effectiveness. Intervention approaches that target executive dysfunction alongside standard PTSD treatments could boost clinical response. The current study reports secondary analyses from a randomized controlled trial testing combined PTSD treatment with a computerized training program to improve executive dysfunction.
View Article and Find Full Text PDFAssociations between hypothalamic-pituitary-adrenal (HPA) axis hormone levels, major depression features and antidepressant effects of ketamine.
J Affect Disord
December 2024
Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address:
Background: Subanesthetic doses of (R,S)-ketamine (ketamine) have demonstrated rapid and robust antidepressant effects in individuals with depression. However, individual variability in response to ketamine exists, and current biomarkers of ketamine treatment response are not entirely understood. Preclinical evidence suggests a link between hypothalamic-pituitary-adrenal (HPA) axis activation, a determinant of the stress response system, and ketamine's efficacy in stressed mice exhibiting enhanced antidepressant responses.
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