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Reliability of Oncology Value Framework Outputs: Concordance Between Independent Research Groups. | LitMetric

AI Article Synopsis

  • Research groups are increasingly using value frameworks for evaluating medical treatments, but their reliability is still not well understood.
  • The study analyzed existing datasets to compare the concordance and reliability of two major frameworks: the ASCO Value Framework (ASCO-VF) and the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS).
  • The findings show that both frameworks have high interrater reliability (ICC of 0.82 for ASCO-VF and 0.88 for ESMO-MCBS), but low absolute agreement on ratings, suggesting careful consideration is needed in their application for drug funding and treatment decisions.

Article Abstract

Research groups are increasingly utilizing value frameworks, but little is known of their reliability. To assess framework concordance and interrater reliability between two major value frameworks currently in use, we identified all previously published datasets containing both scores from the American Society of Clinical Oncology Value Framework (ASCO-VF) and grades from the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS). The intraclass correlation coefficient (ICC) was used to assess interrater reliability. Four eligible studies contained drugs evaluated by both value frameworks, resulting in a dataset of 39 grades/scores for discrete drug indications. ICC was 0.82 (95% confidence interval = 0.70 to 0.90) for ASCO-VF and 0.88 (95% confidence interval = 0.80 to 0.93) for ESMO-MCBS. Absolute concordance was found to be 5% for ASCO-VF and 44% for ESMO-MCBS, increasing to 74% and 80% when deviations within 20 points and 1 grade were considered, respectively. Interrater reliability of ASCO-VF and ESMO-MCBS is, therefore, near perfect, while absolute concordance is poor. This has implications when considering framework outputs in drug funding or treatment decision making.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650061PMC
http://dx.doi.org/10.1093/jncics/pky050DOI Listing

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