AI Article Synopsis
- Two sesquiterpene lactones, 1 ,10,3,4-diepoxyguai-5,6,7-11(13)-en-6,12-olide and hanphyllin, were isolated from the plant Kovalevsk and characterized using advanced techniques like HR-ESI-MS, IR, and NMR.
- The X-ray diffraction analysis provided precise spatial structures of both compounds.
- The chloroform fraction containing these compounds showed stronger cytotoxic effects on HeLa (89.7%) and HEp-2 (63.0%) cancer cells compared to individual compounds and cisplatin, while being less toxic to liver cells.
Article Abstract
The structures and anticancer effects of two sesquiterpene lactones, 1 ,10,3,4-diepoxyguai-5,6,7-11(13)-en-6,12-olide () and hanphyllin () isolated from the aerial part of (Kovalevsk.) Kovalevsk were investigated. The compound was isolated for the first time as a natural compound and its structure was investigated by HR-ESI-MS, IR and NMR techniques. The X-ray diffraction analysis was performed to accurately determine the spatial structures of and . Furthermore, we evaluated the cytotoxic activity of and and the chloroform fraction which contains both of them. Cytotoxic activity revealed that the effect of the chloroform fraction is stronger in growth inhibition of HeLa (89.7%) and HEp-2 (63.0%) cancer cells than the effect of individual compounds (55.9 and 36.3%), (78.6 and 50.3%) and the reference cisplatin (58.0 and 46.8%) respectively. Moreover, the chloroform fraction is less toxic to the hepatocytes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2019.1647423 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!