Overexpression of the global regulator LaeA in a marine-derived fungal strain of YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide () and 10,11,16,17-tetrahydrobislongiquinolide (), as well as four known analogues, bislongiquinolide (), 16,17-dihydrobislongiquinolide (), sohirnone A (), and 2',3'-dihydrosorbicillin (). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in strains to obtain previously undiscovered compounds.
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| http://dx.doi.org/10.3390/md17080446 | DOI Listing |
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