New Trisulfated Steroids from the Vietnamese Marine Sponge and Their PSA Expression and Glucose Uptake Inhibitory Activities.

Seven new unusual polysulfated steroids-topsentiasterol sulfate G (), topsentiasterol sulfate I (), topsentiasterol sulfate H (), bromotopsentiasterol sulfate D (), dichlorotopsentiasterol sulfate D (), bromochlorotopsentiasterol sulfate D (), and 4-hydroxyhalistanol sulfate C (), as well as three previously described-topsentiasterol sulfate D (), chlorotopsentiasterol sulfate D () and iodotopsentiasterol sulfate D () have been isolated from the marine sponge . Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.