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Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? | LitMetric

AI Article Synopsis

  • - There is currently no standard treatment for metastatic uveal melanoma (mUM), making management of the disease challenging.
  • - Although immunotherapy is frequently utilized for mUM, it has not been tested in large phase III clinical trials with checkpoint inhibitors, and only a small percentage of patients benefit from it.
  • - Researchers reviewed the immunological characteristics of mUM to explore whether immunotherapy might still be effective in treating this type of cancer.

Article Abstract

No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721347PMC
http://dx.doi.org/10.3390/cancers11081055DOI Listing

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