Medication-induced xerostomia often results in rampant caries and difficult restorative options. An understanding of which medications contribute to xerostomia and possible methods of palliative care and treatment can help the dental provider to greatly improve the patient's quality of life. This article provides a comprehensive review of medications and risk assessment for patients with medication-induced xerostomia. In addition, the authors suggest palliative and preventive treatments currently recommended for this condition.
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Potential association of anticholinergic medication intake and caries experience in young adults with xerostomia.
J Dent Sci
October 2023
Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, NY, USA.
Background/purpose: Growing prescription of anticholinergic medications has a critical effect on oral health. A link between anticholinergic medication-induced xerostomia (subjective feeling of oral dryness) and a high Decayed, Missing, and Filled teeth (DMFT) index has been reported in the older population. The purpose of this retrospective study is to determine anticholinergic exposure and prevalence of the most frequently used anticholinergic medications in adults 18-44 years of age, as well as to explore xerostomia and its association with caries status.
View Article and Find Full Text PDFAre medication-induced salivary changes the culprit of osteonecrosis of the jaw? A systematic review.
Front Med (Lausanne)
August 2023
OMFS IMPATH Research Group, Department of Oral and Maxillofacial Surgery and Imaging and Pathology, Faculty of Medicine, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Purpose: This systematic review was performed to assess the potential influence of medication-induced salivary changes on the development of medication-related osteonecrosis of the jaw (MRONJ).
Methods: An electronic search was conducted using PubMed, Web of Science, Cochrane, and Embase databases for articles published up to June 2023. A risk of bias assessment was performed according to the modified Newcastle-Ottawa Scale (NOS).
A scoping review on hyposalivation associated with systemic conditions: the role of physical stimulation in the treatment approaches.
BMC Oral Health
July 2023
Department of Dentistry, School of Health Sciences, University of Brasilia, Brasília, Brazil.
Background: Several systemic conditions can result in distinct degrees of salivary gland damage and consequent hypofunction. The development of successful management schemes is highly challenging due to the complexity of saliva. This study aimed to systematically map the literature on the physical stimulation of salivary glands for hyposalivation management and the response of individuals according to different systemic conditions causing salivary impairment.
View Article and Find Full Text PDFObjective: Xerostomia (or oral dryness) is most commonly caused by medications that affect saliva secretion, and is often accompanied by symptoms of orofacial pain. Medication-induced xerostomia may or may not be associated with objectively demonstrable hyposalivation. The present study attempted to systematically identify an association between medication-induced xerostomia and orofacial pain.
View Article and Find Full Text PDFAnticholinergic Medication and Caries Status Predict Xerostomia under 65.
Dent J (Basel)
March 2023
General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA.
The use of anticholinergic medications is increasing in younger ages, yet information about xerostomia, the most common anticholinergic side effect, is limited. This case-control retrospective study examines the relationship between anticholinergic medication-induced xerostomia and caries status among adults between 18 and 65 years of age. The study sample comprised 649 cases with xerostomia and 649 age- and gender-matched controls.
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